Syncope in hypertrophic cardiomyopathy: mechanisms and consequences for treatment

Lynne Williams, Michael Frenneaux

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


Hypertrophic cardiomyopathy (HCM) is an inherited disease with marked phenotypic variability that includes the extent of hypertrophy, the presence and severity of symptoms, and the natural history of the disease. Symptoms of impaired consciousness (syncope and pre-syncope) occur in approximately 15-25% of patients with hypertrophic cardiomyopathy (HCM). In young patients a history of recurrent syncope is associated with an increased risk of sudden death. Detailed investigations identify a probable mechanism in a minority of these, usually paroxysmal atrial fibrillation or ventricular tachycardia. In the majority, however, no likely mechanism is found despite extensive investigation. Although this may be the case, it is still of vital importance to exclude potentially treatable causes of syncope.
Original languageEnglish
Pages (from-to)817-822
Number of pages6
Issue number9
Publication statusPublished - Sep 2007


  • Arrhythmias, Cardiac
  • Cardiomyopathies
  • Cardiomyopathy, Hypertrophic
  • Death, Sudden, Cardiac
  • Defibrillators, Implantable
  • Electrocardiography
  • Humans
  • Phenotype
  • Risk
  • Risk Factors
  • Syncope
  • Tachycardia, Paroxysmal
  • Tachycardia, Ventricular

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