Synthesis and antimicrobial activity of brominated resorcinol dimers

Elise Bouthenet, Ki-Bong Oh, Seungil Park, Navjeet K. Nagi, Hyi-Seung Lee, Susan E. Matthews

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11 Citations (Scopus)

Abstract

Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6’-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase C. albicans.
Original languageEnglish
Pages (from-to)7142-7145
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume23
Issue number23
DOIs
Publication statusPublished - 2011

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