Synthesis and antimicrobial activity of brominated resorcinol dimers

Elise Bouthenet; Ki-Bong Oh; Seungil Park; Navjeet K. Nagi; Hyi-Seung Lee; Susan E. Matthews

doi:10.1016/j.bmcl.2011.09.072

Synthesis and antimicrobial activity of brominated resorcinol dimers

Elise Bouthenet, Ki-Bong Oh, Seungil Park, Navjeet K. Nagi, Hyi-Seung Lee, Susan E. Matthews

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Abstract

Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6’-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase C. albicans.

Original language	English
Pages (from-to)	7142-7145
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	23
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2011.09.072
Publication status	Published - 2011

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10.1016/j.bmcl.2011.09.072

Cite this

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title = "Synthesis and antimicrobial activity of brominated resorcinol dimers",

abstract = "Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6{\textquoteright}-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase C. albicans.",

author = "Elise Bouthenet and Ki-Bong Oh and Seungil Park and Nagi, {Navjeet K.} and Hyi-Seung Lee and Matthews, {Susan E.}",

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AU - Bouthenet, Elise

AU - Oh, Ki-Bong

AU - Park, Seungil

AU - Nagi, Navjeet K.

AU - Lee, Hyi-Seung

AU - Matthews, Susan E.

PY - 2011

Y1 - 2011

N2 - Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6’-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase C. albicans.

AB - Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6’-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase C. albicans.

U2 - 10.1016/j.bmcl.2011.09.072

DO - 10.1016/j.bmcl.2011.09.072

M3 - Article

VL - 23

SP - 7142

EP - 7145

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

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