TY - JOUR
T1 - Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes
AU - Stringer, Tameryn
AU - Hendricks, Denver T.
AU - Guzgay, Hajira
AU - Smith, Gregory S.
PY - 2012/1/4
Y1 - 2012/1/4
N2 - A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-[M(PTA)2Cl2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (1H, 13C{1H} and 31P{1H}) spectroscopy. The data revealed tridentate (O–N–S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. In vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity.
AB - A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-[M(PTA)2Cl2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (1H, 13C{1H} and 31P{1H}) spectroscopy. The data revealed tridentate (O–N–S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. In vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84155172138&partnerID=MN8TOARS
U2 - 10.1016/j.poly.2011.10.005
DO - 10.1016/j.poly.2011.10.005
M3 - Article
VL - 31
SP - 486
EP - 493
JO - Polyhedron
JF - Polyhedron
SN - 0277-5387
IS - 1
ER -
