Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes

Tameryn Stringer; Denver T. Hendricks; Hajira Guzgay; Gregory S. Smith

doi:10.1016/j.poly.2011.10.005

Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes

Tameryn Stringer
, Denver T. Hendricks
, Hajira Guzgay
, Gregory S. Smith

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-[M(PTA)2Cl2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (1H, 13C{1H} and 31P{1H}) spectroscopy. The data revealed tridentate (O–N–S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. In vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity.

Original language	English
Pages (from-to)	486-493
Number of pages	8
Journal	Polyhedron
Volume	31
Issue number	1
Early online date	13 Oct 2011
DOIs	https://doi.org/10.1016/j.poly.2011.10.005
Publication status	Published - 4 Jan 2012

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SDG 3 Good Health and Well-being

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title = "Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes",

abstract = "A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-[M(PTA)2Cl2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (1H, 13C\{1H\} and 31P\{1H\}) spectroscopy. The data revealed tridentate (O–N–S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. In vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity.",

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T1 - Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes

AU - Stringer, Tameryn

AU - Hendricks, Denver T.

AU - Guzgay, Hajira

AU - Smith, Gregory S.

PY - 2012/1/4

Y1 - 2012/1/4

N2 - A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-[M(PTA)2Cl2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (1H, 13C{1H} and 31P{1H}) spectroscopy. The data revealed tridentate (O–N–S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. In vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity.

AB - A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-[M(PTA)2Cl2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (1H, 13C{1H} and 31P{1H}) spectroscopy. The data revealed tridentate (O–N–S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. In vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity.

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JO - Polyhedron

JF - Polyhedron

IS - 1

ER -

Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes

Abstract

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