Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

Lesley Howell, Aaron Howman, Maria O'Connell, Anja Mueller, Mark Searcey

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20 Citations (Scopus)


A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.
Original languageEnglish
Pages (from-to)5880-5883
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Issue number20
Publication statusPublished - 23 Aug 2009

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