Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

Lesley Howell; Aaron Howman; Maria O'Connell; Anja Mueller; Mark Searcey

doi:10.1016/j.bmcl.2009.08.070

Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

Lesley Howell, Aaron Howman, Maria O'Connell, Anja Mueller, Mark Searcey

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.

Original language	English
Pages (from-to)	5880-5883
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	19
Issue number	20
DOIs	https://doi.org/10.1016/j.bmcl.2009.08.070
Publication status	Published - 23 Aug 2009

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10.1016/j.bmcl.2009.08.070

Cite this

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title = "Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry",

abstract = "A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.",

author = "Lesley Howell and Aaron Howman and Maria O'Connell and Anja Mueller and Mark Searcey",

year = "2009",

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doi = "10.1016/j.bmcl.2009.08.070",

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journal = "Bioorganic & Medicinal Chemistry Letters",

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AU - Howell, Lesley

AU - Howman, Aaron

AU - O'Connell, Maria

AU - Mueller, Anja

AU - Searcey, Mark

PY - 2009/8/23

Y1 - 2009/8/23

N2 - A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.

AB - A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.

U2 - 10.1016/j.bmcl.2009.08.070

DO - 10.1016/j.bmcl.2009.08.070

M3 - Article

VL - 19

SP - 5880

EP - 5883

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

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ER -