Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

Lesley Howell; Aaron Howman; Maria O'Connell; Anja Mueller; Mark Searcey

doi:10.1016/j.bmcl.2009.08.070

Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

Lesley Howell
, Aaron Howman
, Maria O'Connell
, Anja Mueller
, Mark Searcey

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.

Original language	English
Pages (from-to)	5880-5883
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	19
Issue number	20
DOIs	https://doi.org/10.1016/j.bmcl.2009.08.070
Publication status	Published - 23 Aug 2009

Access to Document

10.1016/j.bmcl.2009.08.070

Cite this

@article{4a7e8c07e86445e1a9850b43230ae4f8,

title = "Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry",

abstract = "A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.",

author = "Lesley Howell and Aaron Howman and Maria O'Connell and Anja Mueller and Mark Searcey",

year = "2009",

month = aug,

day = "23",

doi = "10.1016/j.bmcl.2009.08.070",

language = "English",

volume = "19",

pages = "5880--5883",

journal = "Bioorganic \& Medicinal Chemistry Letters",

issn = "1464-3405",

publisher = "Elsevier",

number = "20",

}

TY - JOUR

T1 - Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

AU - Howell, Lesley

AU - Howman, Aaron

AU - O'Connell, Maria

AU - Mueller, Anja

AU - Searcey, Mark

PY - 2009/8/23

Y1 - 2009/8/23

N2 - A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.

AB - A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.

U2 - 10.1016/j.bmcl.2009.08.070

DO - 10.1016/j.bmcl.2009.08.070

M3 - Article

SN - 1464-3405

VL - 19

SP - 5880

EP - 5883

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 20

ER -