Synthesis and evaluation of a novel bleomycin A(2) analogue: continuing assessment of the linker domain

Dale L. Boger, Brian M. Aquila, Winston C. Tse, Mark Searcey

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    12 Citations (Scopus)

    Abstract

    The synthesis and evaluation of a bithiazole ester analogue of deglycobleomycin A(2) that addresses the importance of the bithiazole-L-threonine amide for efficient DNA cleavage is described. (C) 2000 Elsevier Science Ltd. Ail rights reserved.
    Original languageEnglish
    Pages (from-to)9493-9498
    Number of pages6
    JournalTetrahedron Letters
    Volume41
    Issue number49
    DOIs
    Publication statusPublished - 2000

    Keywords

    • ACTIVATION
    • ACID
    • BINDING
    • RNA
    • PREORGANIZATION
    • DEGRADATION
    • ANTIBIOTICS
    • SELECTIVE DNA CLEAVAGE
    • NEOCARZINOSTATIN
    • MECHANISMS

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