Synthesis and evaluation of a novel bleomycin A(2) analogue: continuing assessment of the linker domain

Dale L. Boger; Brian M. Aquila; Winston C. Tse; Mark Searcey

doi:10.1016/S0040-4039(00)01633-6

Synthesis and evaluation of a novel bleomycin A(2) analogue: continuing assessment of the linker domain

Dale L. Boger, Brian M. Aquila, Winston C. Tse, Mark Searcey

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The synthesis and evaluation of a bithiazole ester analogue of deglycobleomycin A(2) that addresses the importance of the bithiazole-L-threonine amide for efficient DNA cleavage is described. (C) 2000 Elsevier Science Ltd. Ail rights reserved.

Original language	English
Pages (from-to)	9493-9498
Number of pages	6
Journal	Tetrahedron Letters
Volume	41
Issue number	49
DOIs	https://doi.org/10.1016/S0040-4039(00)01633-6
Publication status	Published - 2000

Keywords

ACTIVATION
ACID
BINDING
RNA
PREORGANIZATION
DEGRADATION
ANTIBIOTICS
SELECTIVE DNA CLEAVAGE
NEOCARZINOSTATIN
MECHANISMS

Access to Document

10.1016/S0040-4039(00)01633-6

Cite this

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title = "Synthesis and evaluation of a novel bleomycin A(2) analogue: continuing assessment of the linker domain",

abstract = "The synthesis and evaluation of a bithiazole ester analogue of deglycobleomycin A(2) that addresses the importance of the bithiazole-L-threonine amide for efficient DNA cleavage is described. (C) 2000 Elsevier Science Ltd. Ail rights reserved.",

keywords = "ACTIVATION, ACID, BINDING, RNA, PREORGANIZATION, DEGRADATION, ANTIBIOTICS, SELECTIVE DNA CLEAVAGE, NEOCARZINOSTATIN, MECHANISMS",

author = "Boger, {Dale L.} and Aquila, {Brian M.} and Tse, {Winston C.} and Mark Searcey",

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pages = "9493--9498",

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AU - Boger, Dale L.

AU - Aquila, Brian M.

AU - Tse, Winston C.

AU - Searcey, Mark

PY - 2000

Y1 - 2000

N2 - The synthesis and evaluation of a bithiazole ester analogue of deglycobleomycin A(2) that addresses the importance of the bithiazole-L-threonine amide for efficient DNA cleavage is described. (C) 2000 Elsevier Science Ltd. Ail rights reserved.

AB - The synthesis and evaluation of a bithiazole ester analogue of deglycobleomycin A(2) that addresses the importance of the bithiazole-L-threonine amide for efficient DNA cleavage is described. (C) 2000 Elsevier Science Ltd. Ail rights reserved.

KW - ACTIVATION

KW - ACID

KW - BINDING

KW - RNA

KW - PREORGANIZATION

KW - DEGRADATION

KW - ANTIBIOTICS

KW - SELECTIVE DNA CLEAVAGE

KW - NEOCARZINOSTATIN

KW - MECHANISMS

U2 - 10.1016/S0040-4039(00)01633-6

DO - 10.1016/S0040-4039(00)01633-6

M3 - Article

VL - 41

SP - 9493

EP - 9498

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

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ER -