Synthesis and evaluation of a novel bleomycin A(2) analogue: continuing assessment of the linker domain

Dale L. Boger, Brian M. Aquila, Winston C. Tse, Mark Searcey

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12 Citations (Scopus)

Abstract

The synthesis and evaluation of a bithiazole ester analogue of deglycobleomycin A(2) that addresses the importance of the bithiazole-L-threonine amide for efficient DNA cleavage is described. (C) 2000 Elsevier Science Ltd. Ail rights reserved.
Original languageEnglish
Pages (from-to)9493-9498
Number of pages6
JournalTetrahedron Letters
Volume41
Issue number49
DOIs
Publication statusPublished - 2000

Keywords

  • ACTIVATION
  • ACID
  • BINDING
  • RNA
  • PREORGANIZATION
  • DEGRADATION
  • ANTIBIOTICS
  • SELECTIVE DNA CLEAVAGE
  • NEOCARZINOSTATIN
  • MECHANISMS

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