Abstract
The synthesis and evaluation of a bithiazole ester analogue of deglycobleomycin A(2) that addresses the importance of the bithiazole-L-threonine amide for efficient DNA cleavage is described. (C) 2000 Elsevier Science Ltd. Ail rights reserved.
Original language | English |
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Pages (from-to) | 9493-9498 |
Number of pages | 6 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 49 |
DOIs | |
Publication status | Published - 2000 |
Keywords
- ACTIVATION
- ACID
- BINDING
- RNA
- PREORGANIZATION
- DEGRADATION
- ANTIBIOTICS
- SELECTIVE DNA CLEAVAGE
- NEOCARZINOSTATIN
- MECHANISMS