Synthesis and evaluation of mimetics of UDP and UDP-α-D-galactose, dTDP and dTDP-α-D-glucose with monosaccharides replacing the key pyrophosphate unit

Lluis Ballell, Robert J. Young, Robert A. Field

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

A series of 5′-O-glycosyl-uridine and thymidine derivatives have been prepared as potential mimics of sugar nucelotides and nucleotide-diphosphates. These compounds proved not to be inhibitors of bovine β-1,4- galactosyltransferase although some showed moderate inhibition of Salmonella dTDP-a-D-glucose 4,6-dehydratase (RmlB).

Original languageEnglish
Pages (from-to)1109-1115
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume3
Issue number6
Early online date21 Feb 2005
DOIs
Publication statusPublished - 21 Mar 2005

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