Synthesis and structural study of two new heparin-like hexasaccharides

Ricardo Lucas, Jesús Angulo, Pedro M Nieto, Manuel Martín-Lomas

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.
Original languageEnglish
Pages (from-to)2253-2266
Number of pages14
JournalOrganic & Biomolecular Chemistry
Volume1
Issue number13
Publication statusPublished - 7 Jul 2003

Keywords

  • Molecular Structure
  • Protein Structure, Secondary
  • Sequence Alignment
  • Models, Molecular
  • Oligosaccharides
  • Molecular Sequence Data
  • Carbohydrate Sequence
  • Protein Structure, Tertiary
  • Heparin
  • Protein Conformation
  • Magnetic Resonance Spectroscopy

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