Abstract
Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.
| Original language | English |
|---|---|
| Pages (from-to) | 2253-2266 |
| Number of pages | 14 |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 1 |
| Issue number | 13 |
| Publication status | Published - 7 Jul 2003 |
Keywords
- Molecular Structure
- Protein Structure, Secondary
- Sequence Alignment
- Models, Molecular
- Oligosaccharides
- Molecular Sequence Data
- Carbohydrate Sequence
- Protein Structure, Tertiary
- Heparin
- Protein Conformation
- Magnetic Resonance Spectroscopy