Synthesis and structural study of two new heparin-like hexasaccharides

Ricardo Lucas; Jesús Angulo; Pedro M. Nieto; Manuel Martín-Lomas

Synthesis and structural study of two new heparin-like hexasaccharides

Ricardo Lucas, Jesús Angulo, Pedro M. Nieto, Manuel Martín-Lomas

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.

Original language	English
Pages (from-to)	2253-2266
Number of pages	14
Journal	Organic & Biomolecular Chemistry
Volume	1
Issue number	13
Publication status	Published - 7 Jul 2003

Keywords

Molecular Structure
Protein Structure, Secondary
Sequence Alignment
Models, Molecular
Oligosaccharides
Molecular Sequence Data
Carbohydrate Sequence
Protein Structure, Tertiary
Heparin
Protein Conformation
Magnetic Resonance Spectroscopy

Access to Document

https://pubs.rsc.org/en/content/articlelanding/2003/ob/b303115b#!

Cite this

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title = "Synthesis and structural study of two new heparin-like hexasaccharides",

abstract = "Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.",

keywords = "Molecular Structure, Protein Structure, Secondary, Sequence Alignment, Models, Molecular, Oligosaccharides, Molecular Sequence Data, Carbohydrate Sequence, Protein Structure, Tertiary, Heparin, Protein Conformation, Magnetic Resonance Spectroscopy",

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AU - Lucas, Ricardo

AU - Angulo, Jesús

AU - Nieto, Pedro M.

AU - Martín-Lomas, Manuel

PY - 2003/7/7

Y1 - 2003/7/7

N2 - Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.

AB - Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.

KW - Molecular Structure

KW - Protein Structure, Secondary

KW - Sequence Alignment

KW - Models, Molecular

KW - Oligosaccharides

KW - Molecular Sequence Data

KW - Carbohydrate Sequence

KW - Protein Structure, Tertiary

KW - Heparin

KW - Protein Conformation

KW - Magnetic Resonance Spectroscopy

M3 - Article

C2 - 12945695

SN - 1477-0520

VL - 1

SP - 2253

EP - 2266

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 13

ER -