Synthesis of an isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B receptor antagonist tetronothiodin

Philip C. Bulman Page; Hooshang Vahedi; Kevin J. Batchelor; Stephen Hindley; Mark Edgar; Paul Beswick

doi:10.1055/s-2003-39287

Synthesis of an isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B receptor antagonist tetronothiodin

Philip C. Bulman Page, Hooshang Vahedi, Kevin J. Batchelor, Stephen Hindley, Mark Edgar, Paul Beswick

Chemistry of Materials and Catalysis

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

An isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B Receptor antagonist tetronothiodin, diastereoisomeric at the spiro centre, has been synthesized in five steps from dienol 4.

Original language	English
Pages (from-to)	1022-1024
Number of pages	3
Journal	Synlett
Issue number	7
DOIs	https://doi.org/10.1055/s-2003-39287
Publication status	Published - 2003

Keywords

TOP-HALF
Dieckmann
STREPTOMYCES SP-NR0489
tetronothiodin
CCK
CHLOROTHRICOLIDE
CHOLECYSTOKININ
spiro tetronic acid
Diels-Alder

Access to Document

10.1055/s-2003-39287

Cite this

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title = "Synthesis of an isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B receptor antagonist tetronothiodin",

abstract = "An isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B Receptor antagonist tetronothiodin, diastereoisomeric at the spiro centre, has been synthesized in five steps from dienol 4.",

keywords = "TOP-HALF, Dieckmann, STREPTOMYCES SP-NR0489, tetronothiodin, CCK, CHLOROTHRICOLIDE, CHOLECYSTOKININ, spiro tetronic acid, Diels-Alder",

author = "{Bulman Page}, {Philip C.} and Hooshang Vahedi and Batchelor, {Kevin J.} and Stephen Hindley and Mark Edgar and Paul Beswick",

year = "2003",

doi = "10.1055/s-2003-39287",

language = "English",

pages = "1022--1024",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "7",

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T1 - Synthesis of an isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B receptor antagonist tetronothiodin

AU - Bulman Page, Philip C.

AU - Vahedi, Hooshang

AU - Batchelor, Kevin J.

AU - Hindley, Stephen

AU - Edgar, Mark

AU - Beswick, Paul

PY - 2003

Y1 - 2003

N2 - An isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B Receptor antagonist tetronothiodin, diastereoisomeric at the spiro centre, has been synthesized in five steps from dienol 4.

AB - An isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B Receptor antagonist tetronothiodin, diastereoisomeric at the spiro centre, has been synthesized in five steps from dienol 4.

KW - TOP-HALF

KW - Dieckmann

KW - STREPTOMYCES SP-NR0489

KW - tetronothiodin

KW - CCK

KW - CHLOROTHRICOLIDE

KW - CHOLECYSTOKININ

KW - spiro tetronic acid

KW - Diels-Alder

U2 - 10.1055/s-2003-39287

DO - 10.1055/s-2003-39287

M3 - Article

SP - 1022

EP - 1024

JO - Synlett

JF - Synlett

SN - 0936-5214

IS - 7

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