Synthesis of an isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B receptor antagonist tetronothiodin

Philip C. Bulman Page, Hooshang Vahedi, Kevin J. Batchelor, Stephen Hindley, Mark Edgar, Paul Beswick

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25 Citations (Scopus)

Abstract

An isomer of the oxaspirobicyclic tetronic acid unit of the CCK-B Receptor antagonist tetronothiodin, diastereoisomeric at the spiro centre, has been synthesized in five steps from dienol 4.
Original languageEnglish
Pages (from-to)1022-1024
Number of pages3
JournalSynlett
Issue number7
DOIs
Publication statusPublished - 2003

Keywords

  • TOP-HALF
  • Dieckmann
  • STREPTOMYCES SP-NR0489
  • tetronothiodin
  • CCK
  • CHLOROTHRICOLIDE
  • CHOLECYSTOKININ
  • spiro tetronic acid
  • Diels-Alder

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