Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption

Philip C. Bulman Page; Jonathan P. G. Moore; Ian Mansfield; Michael J. McKenzie; Wayne B. Bowler; James A. Gallagher

doi:10.1016/S0040-4020(00)01164-9

Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption

Philip C. Bulman Page, Jonathan P. G. Moore, Ian Mansfield, Michael J. McKenzie, Wayne B. Bowler, James A. Gallagher

Chemistry of Materials and Catalysis

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

Syntheses have been realised for several members of a new class of potential bone resorption inhibitors consisting of steroidal oestrogenic compounds linked at the 17 position to a geminal bia(phosphonic acid) moiety through an ester linkage. The approach used has the potential to allow other biologically active compounds to be coupled to the geminal bisphosphonate unit. (C) 2001 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	1837-1847
Number of pages	11
Journal	Tetrahedron
Volume	57
Issue number	9
DOIs	https://doi.org/10.1016/S0040-4020(00)01164-9
Publication status	Published - 2001

Keywords

RISK
bisphosphonate
targeting
OSTEOPOROSIS
oestrogen
ESTROGEN
BISPHOSPHONATES
BREAST-CANCER
ALENDRONATE
OVARIECTOMIZED RATS
POSTMENOPAUSAL WOMEN
OSTEOBLASTS
MECHANISMS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0040-4020(00)01164-9

Cite this

@article{6e8c18c910a6430897d054562ca8fb4d,

title = "Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption",

abstract = "Syntheses have been realised for several members of a new class of potential bone resorption inhibitors consisting of steroidal oestrogenic compounds linked at the 17 position to a geminal bia(phosphonic acid) moiety through an ester linkage. The approach used has the potential to allow other biologically active compounds to be coupled to the geminal bisphosphonate unit. (C) 2001 Elsevier Science Ltd. All rights reserved.",

keywords = "RISK, bisphosphonate, targeting, OSTEOPOROSIS, oestrogen, ESTROGEN, BISPHOSPHONATES, BREAST-CANCER, ALENDRONATE, OVARIECTOMIZED RATS, POSTMENOPAUSAL WOMEN, OSTEOBLASTS, MECHANISMS",

author = "{Bulman Page}, {Philip C.} and Moore, {Jonathan P. G.} and Ian Mansfield and McKenzie, {Michael J.} and Bowler, {Wayne B.} and Gallagher, {James A.}",

year = "2001",

doi = "10.1016/S0040-4020(00)01164-9",

language = "English",

volume = "57",

pages = "1837--1847",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier",

number = "9",

}

TY - JOUR

T1 - Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption

AU - Bulman Page, Philip C.

AU - Moore, Jonathan P. G.

AU - Mansfield, Ian

AU - McKenzie, Michael J.

AU - Bowler, Wayne B.

AU - Gallagher, James A.

PY - 2001

Y1 - 2001

N2 - Syntheses have been realised for several members of a new class of potential bone resorption inhibitors consisting of steroidal oestrogenic compounds linked at the 17 position to a geminal bia(phosphonic acid) moiety through an ester linkage. The approach used has the potential to allow other biologically active compounds to be coupled to the geminal bisphosphonate unit. (C) 2001 Elsevier Science Ltd. All rights reserved.

AB - Syntheses have been realised for several members of a new class of potential bone resorption inhibitors consisting of steroidal oestrogenic compounds linked at the 17 position to a geminal bia(phosphonic acid) moiety through an ester linkage. The approach used has the potential to allow other biologically active compounds to be coupled to the geminal bisphosphonate unit. (C) 2001 Elsevier Science Ltd. All rights reserved.

KW - RISK

KW - bisphosphonate

KW - targeting

KW - OSTEOPOROSIS

KW - oestrogen

KW - ESTROGEN

KW - BISPHOSPHONATES

KW - BREAST-CANCER

KW - ALENDRONATE

KW - OVARIECTOMIZED RATS

KW - POSTMENOPAUSAL WOMEN

KW - OSTEOBLASTS

KW - MECHANISMS

U2 - 10.1016/S0040-4020(00)01164-9

DO - 10.1016/S0040-4020(00)01164-9

M3 - Article

VL - 57

SP - 1837

EP - 1847

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 9

ER -