Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption

Philip C. Bulman Page, Jonathan P. G. Moore, Ian Mansfield, Michael J. McKenzie, Wayne B. Bowler, James A. Gallagher

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Abstract

Syntheses have been realised for several members of a new class of potential bone resorption inhibitors consisting of steroidal oestrogenic compounds linked at the 17 position to a geminal bia(phosphonic acid) moiety through an ester linkage. The approach used has the potential to allow other biologically active compounds to be coupled to the geminal bisphosphonate unit. (C) 2001 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)1837-1847
Number of pages11
JournalTetrahedron
Volume57
Issue number9
DOIs
Publication statusPublished - 2001

Keywords

  • RISK
  • bisphosphonate
  • targeting
  • OSTEOPOROSIS
  • oestrogen
  • ESTROGEN
  • BISPHOSPHONATES
  • BREAST-CANCER
  • ALENDRONATE
  • OVARIECTOMIZED RATS
  • POSTMENOPAUSAL WOMEN
  • OSTEOBLASTS
  • MECHANISMS

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