Syntheses have been realised for several members of a new class of potential bone resorption inhibitors consisting of steroidal oestrogenic compounds linked at the 17 position to a geminal bia(phosphonic acid) moiety through an ester linkage. The approach used has the potential to allow other biologically active compounds to be coupled to the geminal bisphosphonate unit. (C) 2001 Elsevier Science Ltd. All rights reserved.
- OVARIECTOMIZED RATS
- POSTMENOPAUSAL WOMEN