Synthesis of C -propargylic esters of N-protected amino acids and peptides

S.P. Bew, G.D. Hiatt-Gipson

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16 Citations (Scopus)

Abstract

Figure presented Recent years have seen a huge surge of interest in the application of alkyne-derived motifs for so-called "click" chemistry. Given the critical importance of amino acids in organic synthesis as well as their myriad of applications in "click" chemistry it is interesting to note that the synthesis of C-propargyl derived amino acid esters has not been particularly well served. We report a convenient, straightforward, and high-yielding synthesis of structurally diverse C-propargyl-derived N-protected amino acid esters. © 2010 American Chemical Society.
Original languageEnglish
Pages (from-to)3897-3899
Number of pages3
JournalThe Journal of Organic Chemistry
Volume75
Issue number11
DOIs
Publication statusPublished - 4 Jun 2010

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