Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride

Dale L. Boger, Christopher W. Boyce, Robert M. Garbaccio, Mark Searcey

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The 5-exo-trig radical cyclization of an aryl halide onto a tethered vinyl chloride produces the 3-chloromethyl dihydroindole precursors for CC- 1065 and duocarmycin analogs with chlorine installed as a suitable leaving group for subsequent cyclopropane spirocyclization. The generality of this approach was examined in the context of six CC-1065 and duocarmycin analogs previously synthesized in this laboratory.

Original languageEnglish
Pages (from-to)2227-2230
Number of pages4
JournalTetrahedron Letters
Issue number16
Publication statusPublished - 16 Apr 1998
Externally publishedYes

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