Synthesis of duocarmycin analogues

Michael J. Stephenson (Inventor), Lesley A. Howell (Inventor), Mark Searcey (Inventor)

Research output: Patent


A novel Fmoc protected duocarmycin subunit and utilization as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid phase peptide synthesis, and in particular a method for the production of novel intermediates and novel monomeric and extended duocarmycin analogues having amino acid substituents.
Original languageEnglish
Patent numberUS9765077B2
Priority date29/05/15
Filing date29/05/15
Publication statusPublished - 19 Sep 2017

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