Synthesis of duocarmycin analogues

Michael J. Stephenson; Lesley A. Howell; Mark Searcey

Synthesis of duocarmycin analogues

Michael J. Stephenson (Inventor)
, Lesley A. Howell (Inventor)
, Mark Searcey (Inventor)

Synthetic and Medicinal Chemistry

Research output: Patent

Abstract

A novel Fmoc protected duocarmycin subunit and utilization as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid phase peptide synthesis, and in particular a method for the production of novel intermediates and novel monomeric and extended duocarmycin analogues having amino acid substituents.

Original language	English
Patent number	US9765077B2
Priority date	29/05/15
Filing date	29/05/15
Publication status	Published - 19 Sept 2017

Cite this

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title = "Synthesis of duocarmycin analogues",

abstract = "A novel Fmoc protected duocarmycin subunit and utilization as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid phase peptide synthesis, and in particular a method for the production of novel intermediates and novel monomeric and extended duocarmycin analogues having amino acid substituents.",

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AU - Searcey, Mark

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AB - A novel Fmoc protected duocarmycin subunit and utilization as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid phase peptide synthesis, and in particular a method for the production of novel intermediates and novel monomeric and extended duocarmycin analogues having amino acid substituents.

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