Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

Stephanie J. Lucas; Rianne Lord; Rachel L.  Wilson; Roger M.  Phillips; Visuvanathar Sridharan; Patrick C. McGowan

doi:10.1039/C2DT32104A

Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

Stephanie J. Lucas
, Rianne Lord
, Rachel L. Wilson
, Roger M. Phillips
, Visuvanathar Sridharan
, Patrick C. McGowan

Centre for Molecular and Structural Biochemistry

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Several Ru-arene and Ir–Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.

Original language	English
Pages (from-to)	13800-13802
Number of pages	3
Journal	Dalton Transactions
Volume	41
DOIs	https://doi.org/10.1039/C2DT32104A
Publication status	Published - 14 Sept 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1039/C2DT32104A

Cite this

@article{ca02caaa7469419981ec27c71276d93c,

title = "Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents",

abstract = "Several Ru-arene and Ir{\textendash}Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased. ",

author = "Lucas, \{Stephanie J.\} and Rianne Lord and Wilson, \{Rachel L.\} and Phillips, \{Roger M.\} and Visuvanathar Sridharan and McGowan, \{Patrick C.\}",

year = "2012",

month = sep,

day = "14",

doi = "10.1039/C2DT32104A",

language = "English",

volume = "41",

pages = "13800--13802",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

AU - Lucas, Stephanie J.

AU - Lord, Rianne

AU - Wilson, Rachel L.

AU - Phillips, Roger M.

AU - Sridharan, Visuvanathar

AU - McGowan, Patrick C.

PY - 2012/9/14

Y1 - 2012/9/14

N2 - Several Ru-arene and Ir–Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.

AB - Several Ru-arene and Ir–Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.

U2 - 10.1039/C2DT32104A

DO - 10.1039/C2DT32104A

M3 - Article

SN - 1477-9226

VL - 41

SP - 13800

EP - 13802

JO - Dalton Transactions

JF - Dalton Transactions

ER -