Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi

Renate M. Van Well, Beatrice Y.M. Collet, Robert A. Field

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16 Citations (Scopus)

Abstract

A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase.

Original languageEnglish
Pages (from-to)2175-2177
Number of pages3
JournalSynlett
Issue number14
DOIs
Publication statusPublished - 22 Aug 2008

Keywords

  • Drug target
  • Mucin
  • Oligosaccharide
  • Parasite
  • Synthesis
  • Trans-sialidase

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