Abstract
A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase.
Original language | English |
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Pages (from-to) | 2175-2177 |
Number of pages | 3 |
Journal | Synlett |
Issue number | 14 |
DOIs | |
Publication status | Published - 22 Aug 2008 |
Keywords
- Drug target
- Mucin
- Oligosaccharide
- Parasite
- Synthesis
- Trans-sialidase