Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi

Renate M. Van Well; Beatrice Y.M. Collet; Robert A. Field

doi:10.1055/s-2008-1078249

Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi

Renate M. Van Well, Beatrice Y.M. Collet, Robert A. Field

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase.

Original language	English
Pages (from-to)	2175-2177
Number of pages	3
Journal	Synlett
Issue number	14
DOIs	https://doi.org/10.1055/s-2008-1078249
Publication status	Published - 22 Aug 2008

Keywords

Drug target
Mucin
Oligosaccharide
Parasite
Synthesis
Trans-sialidase

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10.1055/s-2008-1078249

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title = "Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi",

abstract = "A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase.",

keywords = "Drug target, Mucin, Oligosaccharide, Parasite, Synthesis, Trans-sialidase",

author = "{Van Well}, {Renate M.} and Collet, {Beatrice Y.M.} and Field, {Robert A.}",

year = "2008",

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language = "English",

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AU - Van Well, Renate M.

AU - Collet, Beatrice Y.M.

AU - Field, Robert A.

PY - 2008/8/22

Y1 - 2008/8/22

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AB - A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase.

KW - Drug target

KW - Mucin

KW - Oligosaccharide

KW - Parasite

KW - Synthesis

KW - Trans-sialidase

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SP - 2175

EP - 2177

JO - Synlett

JF - Synlett

IS - 14

ER -

Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi

Abstract

Keywords

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