Abstract
N-Acyl-N,O-acetals are present in a number of bioactive natural products, and this unusual functional group can act as a synthetic precursor to unstable reactive N-acylimines. In this paper, a variety of N-acyl-O-ethyl-N,O-acetals was concisely prepared under mild conditions mediated by titanium ethoxide (Ti(OEt)4). The method also offers a new strategy to make other O-alkyl-N,O-acetals. Furthermore, this strategy was extended to the synthesis of an analogue of the natural product turtschamide.
Original language | English |
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Pages (from-to) | 10-13 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 16 |
Issue number | 1 |
Early online date | 5 Dec 2013 |
DOIs | |
Publication status | Published - 3 Jan 2014 |