Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway

Diane Robbins, Annabella F. Newton, Camille Gignoux, Jean-Christophe Legeay, Alex Sinclair, Martin Rejzek, Carly A. Laxon, Sai K. Yalamanchili, William Lewis, Maria A. O'Connell, Robert A. Stockman

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Tying the knot! The marriage of two-directional synthesis and tandem reactions allows access to twelve skeletally diverse scaffolds in just fifteen reactions. Two-directional synthesis yields a symmetrical linear “rope-like” keto-dienoate which is then subjected to twelve separate tandem reactions to “tie the rope in knots” thus creating twelve diverse natural product-like scaffolds containing useful functionality for further elaboration.
Original languageEnglish
Pages (from-to)2232-2235
Number of pages4
JournalChemical Science
Issue number2
Publication statusPublished - 2011

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