Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway

Diane Robbins; Annabella F. Newton; Camille Gignoux; Jean-Christophe Legeay; Alex Sinclair; Martin Rejzek; Carly A. Laxon; Sai K. Yalamanchili; William Lewis; Maria A. O'Connell; Robert A. Stockman

doi:10.1039/C1SC00371B

Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway

Diane Robbins, Annabella F. Newton, Camille Gignoux, Jean-Christophe Legeay, Alex Sinclair, Martin Rejzek, Carly A. Laxon, Sai K. Yalamanchili, William Lewis, Maria A. O'Connell, Robert A. Stockman

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Tying the knot! The marriage of two-directional synthesis and tandem reactions allows access to twelve skeletally diverse scaffolds in just fifteen reactions. Two-directional synthesis yields a symmetrical linear “rope-like” keto-dienoate which is then subjected to twelve separate tandem reactions to “tie the rope in knots” thus creating twelve diverse natural product-like scaffolds containing useful functionality for further elaboration.

Original language	English
Pages (from-to)	2232-2235
Number of pages	4
Journal	Chemical Science
Volume	11
Issue number	2
DOIs	https://doi.org/10.1039/C1SC00371B
Publication status	Published - 2011

Access to Document

10.1039/C1SC00371B

Cite this

@article{97de36c0ba5a42b2b33dbaa938fcc63f,

title = "Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway",

abstract = "Tying the knot! The marriage of two-directional synthesis and tandem reactions allows access to twelve skeletally diverse scaffolds in just fifteen reactions. Two-directional synthesis yields a symmetrical linear “rope-like” keto-dienoate which is then subjected to twelve separate tandem reactions to “tie the rope in knots” thus creating twelve diverse natural product-like scaffolds containing useful functionality for further elaboration.",

author = "Diane Robbins and Newton, {Annabella F.} and Camille Gignoux and Jean-Christophe Legeay and Alex Sinclair and Martin Rejzek and Laxon, {Carly A.} and Yalamanchili, {Sai K.} and William Lewis and O'Connell, {Maria A.} and Stockman, {Robert A.}",

year = "2011",

doi = "10.1039/C1SC00371B",

language = "English",

volume = "11",

pages = "2232--2235",

journal = "Chemical Science",

issn = "2041-6520",

publisher = "Royal Society of Chemistry",

number = "2",

}

TY - JOUR

T1 - Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway

AU - Robbins, Diane

AU - Newton, Annabella F.

AU - Gignoux, Camille

AU - Legeay, Jean-Christophe

AU - Sinclair, Alex

AU - Rejzek, Martin

AU - Laxon, Carly A.

AU - Yalamanchili, Sai K.

AU - Lewis, William

AU - O'Connell, Maria A.

AU - Stockman, Robert A.

PY - 2011

Y1 - 2011

N2 - Tying the knot! The marriage of two-directional synthesis and tandem reactions allows access to twelve skeletally diverse scaffolds in just fifteen reactions. Two-directional synthesis yields a symmetrical linear “rope-like” keto-dienoate which is then subjected to twelve separate tandem reactions to “tie the rope in knots” thus creating twelve diverse natural product-like scaffolds containing useful functionality for further elaboration.

AB - Tying the knot! The marriage of two-directional synthesis and tandem reactions allows access to twelve skeletally diverse scaffolds in just fifteen reactions. Two-directional synthesis yields a symmetrical linear “rope-like” keto-dienoate which is then subjected to twelve separate tandem reactions to “tie the rope in knots” thus creating twelve diverse natural product-like scaffolds containing useful functionality for further elaboration.

U2 - 10.1039/C1SC00371B

DO - 10.1039/C1SC00371B

M3 - Article

VL - 11

SP - 2232

EP - 2235

JO - Chemical Science

JF - Chemical Science

SN - 2041-6520

IS - 2

ER -