Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin

Christian Bernlind; Steven W. Homans; Robert A. Field

doi:10.1016/j.tetlet.2009.02.131

Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin

Christian Bernlind, Steven W. Homans, Robert A. Field

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb₄ glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block.

Original language	English
Pages (from-to)	3397-3399
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	26
Early online date	21 Feb 2009
DOIs	https://doi.org/10.1016/j.tetlet.2009.02.131
Publication status	Published - 1 Jul 2009

Keywords

Disaccharide
Gb
Glycosylation
Intramolecular aglycone delivery (IAD)
Verotoxin

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10.1016/j.tetlet.2009.02.131

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title = "Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin",

abstract = "The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb4 glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block.",

keywords = "Disaccharide, Gb, Glycosylation, Intramolecular aglycone delivery (IAD), Verotoxin",

author = "Christian Bernlind and Homans, {Steven W.} and Field, {Robert A.}",

note = "Funding Information: We acknowledge support from the BBSRC and the Knut and Alice Wallenberg Foundation (fellowship to C.B.). ",

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AU - Bernlind, Christian

AU - Homans, Steven W.

AU - Field, Robert A.

N1 - Funding Information: We acknowledge support from the BBSRC and the Knut and Alice Wallenberg Foundation (fellowship to C.B.).

PY - 2009/7/1

Y1 - 2009/7/1

N2 - The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb4 glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block.

AB - The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb4 glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block.

KW - Disaccharide

KW - Gb

KW - Glycosylation

KW - Intramolecular aglycone delivery (IAD)

KW - Verotoxin

UR - http://www.scopus.com/inward/record.url?scp=65549125049&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2009.02.131

DO - 10.1016/j.tetlet.2009.02.131

M3 - Article

AN - SCOPUS:65549125049

VL - 50

SP - 3397

EP - 3399

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 26

ER -

Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin

Abstract

Keywords

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