Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry

P. E. Silva Júnior; L. C D Rezende; Julia Possamai Gimenes; Vinícius Goncąlves Maltarollo; James Dale; G. H G Trossini; F. S. Emery; A. Ganesan

doi:10.1039/c6ra01099g

Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry

P. E. Silva Júnior, L. C D Rezende, Julia Possamai Gimenes, Vinícius Goncąlves Maltarollo, James Dale, G. H G Trossini, F. S. Emery, A. Ganesan

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale.

Original language	English
Pages (from-to)	22777-22780
Number of pages	4
Journal	RSC Advances
Volume	6
Issue number	27
DOIs	https://doi.org/10.1039/c6ra01099g
Publication status	Published - 22 Feb 2016

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10.1039/c6ra01099g

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title = "Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry",

abstract = "In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale.",

author = "{Silva J{\'u}nior}, {P. E.} and Rezende, {L. C D} and Gimenes, {Julia Possamai} and Maltarollo, {Vin{\'i}cius Gonc{\c a}lves} and James Dale and Trossini, {G. H G} and Emery, {F. S.} and A. Ganesan",

year = "2016",

month = feb,

day = "22",

doi = "10.1039/c6ra01099g",

language = "English",

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issn = "2046-2069",

publisher = "Royal Society of Chemistry",

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Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry. / Silva Júnior, P. E.; Rezende, L. C D; Gimenes, Julia Possamai; Maltarollo, Vinícius Goncąlves; Dale, James; Trossini, G. H G; Emery, F. S.; Ganesan, A.

In: RSC Advances, Vol. 6, No. 27, 22.02.2016, p. 22777-22780.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry

AU - Silva Júnior, P. E.

AU - Rezende, L. C D

AU - Gimenes, Julia Possamai

AU - Maltarollo, Vinícius Goncąlves

AU - Dale, James

AU - Trossini, G. H G

AU - Emery, F. S.

AU - Ganesan, A.

PY - 2016/2/22

Y1 - 2016/2/22

N2 - In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale.

AB - In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale.

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U2 - 10.1039/c6ra01099g

DO - 10.1039/c6ra01099g

M3 - Article

AN - SCOPUS:84961208250

VL - 6

SP - 22777

EP - 22780

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 27

ER -

Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry

Abstract

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