Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry

P. E. Silva Júnior; L. C D Rezende; Julia Possamai Gimenes; Vinícius Goncąlves Maltarollo; James Dale; G. H G Trossini; F. S. Emery; A. Ganesan

doi:10.1039/c6ra01099g

Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry

P. E. Silva Júnior, L. C D Rezende, Julia Possamai Gimenes, Vinícius Goncąlves Maltarollo, James Dale, G. H G Trossini, F. S. Emery, A. Ganesan

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale.

Original language	English
Pages (from-to)	22777-22780
Number of pages	4
Journal	RSC Advances
Volume	6
Issue number	27
DOIs	https://doi.org/10.1039/c6ra01099g
Publication status	Published - 22 Feb 2016

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abstract = "In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale.",

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AU - Silva Júnior, P. E.

AU - Rezende, L. C D

AU - Gimenes, Julia Possamai

AU - Maltarollo, Vinícius Goncąlves

AU - Dale, James

AU - Trossini, G. H G

AU - Emery, F. S.

AU - Ganesan, A.

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AB - In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale.

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Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry

Abstract

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