Synthetic glycans, glycoarrays, and glyconanoparticles to investigate host infection by trypanosoma cruzi

Robert A. Field, Peterson Andrade, Vanessa L. Campo, Ivone Carvalho, Beatrice Y. M. Collet, Paul R. Crocker, Margherita Fais, Rositsa Karamanska, Balaram Mukhopadhayay, Sergey A. Nepogodiev, Abdul Rashid, Martin Rejzek, David A. Russell, Claire L. Schofield, Renate M. Van Well

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    Carbohydrate libraries, synthetic glycans and glycopeptides are contributing to understanding of the role of sialic acid recognition in host infection by the parasite Trypanosoma cruzi. Further, glycoarray approaches are allowing us to explore similarities and differences in the carbohydrate-binding specificity of host lectins while glyconanoparticles enable us to ask questions about the structure, sialylation and recognition of parasite mucins.

    Original languageEnglish
    Title of host publicationPetite and Sweet
    Subtitle of host publicationGlyco-Nanotechnology as a Bridge to New Medicines
    PublisherAmerican Chemical Society
    Pages143-159
    Number of pages17
    ISBN (Print)9780841226883
    DOIs
    Publication statusPublished - 2011

    Publication series

    NameACS Symposium Series
    Volume1091
    ISSN (Print)0097-6156
    ISSN (Electronic)1947-5918

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