Synthetic macrocyclic peptidomimetics as tunable pH probes for the fluorescence imaging of acidic organelles in live cells

Francisco Galindo; M. Isabel Burguete; Laura Vigara; Santiago V. Luis; Nurul Kabir; Jelena Gavrilovic; David A. Russell

doi:10.1002/anie.200501920

Synthetic macrocyclic peptidomimetics as tunable pH probes for the fluorescence imaging of acidic organelles in live cells

Francisco Galindo, M. Isabel Burguete, Laura Vigara, Santiago V. Luis, Nurul Kabir, Jelena Gavrilovic, David A. Russell

Research output: Contribution to journal › Article › peer-review

148 Citations (Scopus)

Abstract

Acid test: Macrocyclic compounds that comprise a 9,10-anthracene subunit linked by a C2-symmetric peptidomimetic chain (see formula) are useful as fluorescent probes in a pH range of biomedical interest. Changes in the size of the macrocycle (n=3,4,6,8) produce a shift in the pKa values. Experiments with live mouse macrophage cells show the selective localization of the probe in the acidic organelles (see differential interference contrast image).

Original language	English
Pages (from-to)	6504-6508
Number of pages	5
Journal	Angewandte Chemie International Edition
Volume	44
Issue number	40
DOIs	https://doi.org/10.1002/anie.200501920
Publication status	Published - 2005

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10.1002/anie.200501920

Cite this

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abstract = "Acid test: Macrocyclic compounds that comprise a 9,10-anthracene subunit linked by a C2-symmetric peptidomimetic chain (see formula) are useful as fluorescent probes in a pH range of biomedical interest. Changes in the size of the macrocycle (n=3,4,6,8) produce a shift in the pKa values. Experiments with live mouse macrophage cells show the selective localization of the probe in the acidic organelles (see differential interference contrast image).",

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AU - Galindo, Francisco

AU - Burguete, M. Isabel

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AU - Luis, Santiago V.

AU - Kabir, Nurul

AU - Gavrilovic, Jelena

AU - Russell, David A.

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DO - 10.1002/anie.200501920

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