Systematic identification of genomic markers of drug sensitivity in cancer cells

Mathew J. Garnett; Elena J. Edelman; Sonja J. Heidorn; Anahita Dastur; King Wai Lau; Patricia Greninger; I. Richard Thompson; Xi Luo; Jorge Soares; Qingsong Liu; Francesco Iorio; Didier Surdez; Li Chen; Randy J. Milano; Graham R. Bignell; Ah T. Tam; Helen Davies; Jesse A. Stevenson; Syd Barthorpe; Stephen R. Lutz; Fiona Kogera; Karl Lawrence; Anne Mclaren-douglas; Xeni Mitropoulos; Tatiana Mironenko; Helen Thi; Laura Richardson; Wenjun Zhou; Frances Jewitt; Tinghu Zhang; Patrick O'Brien; Jessica L. Boisvert; Stacey Price; Wooyoung Hur; Wanjuan Yang; Xianming Deng; Adam Butler; Hwan Geun Choi; Jae Won Chang; Jose Baselga; Ivan Stamenkovic; Jeffrey A. Engelman; Sreenath V. Sharma; Olivier Delattre; Julio Saez-rodriguez; Nathanael S. Gray; Jeffrey Settleman; P. Andrew Futreal; Daniel A. Haber; Michael R. Stratton; Sridhar Ramaswamy; Ultan Mcdermott; Cyril H. Benes; Christopher Greenman

doi:10.1038/nature11005

Systematic identification of genomic markers of drug sensitivity in cancer cells

Mathew J. Garnett, Elena J. Edelman, Sonja J. Heidorn, Anahita Dastur, King Wai Lau, Patricia Greninger, I. Richard Thompson, Xi Luo, Jorge Soares, Qingsong Liu, Francesco Iorio, Didier Surdez, Li Chen, Randy J. Milano, Graham R. Bignell, Ah T. Tam, Helen Davies, Jesse A. Stevenson, Syd Barthorpe, Stephen R. LutzFiona Kogera, Karl Lawrence, Anne Mclaren-douglas, Xeni Mitropoulos, Tatiana Mironenko, Helen Thi, Laura Richardson, Wenjun Zhou, Frances Jewitt, Tinghu Zhang, Patrick O'Brien, Jessica L. Boisvert, Stacey Price, Wooyoung Hur, Wanjuan Yang, Xianming Deng, Adam Butler, Hwan Geun Choi, Jae Won Chang, Jose Baselga, Ivan Stamenkovic, Jeffrey A. Engelman, Sreenath V. Sharma, Olivier Delattre, Julio Saez-rodriguez, Nathanael S. Gray, Jeffrey Settleman, P. Andrew Futreal, Daniel A. Haber, Michael R. Stratton, Sridhar Ramaswamy, Ultan Mcdermott, Cyril H. Benes, Christopher Greenman

Research output: Contribution to journal › Article › peer-review

1762 Citations (Scopus)

Original language	English
Pages (from-to)	570-575
Journal	Nature
Volume	483
Issue number	7391
DOIs	https://doi.org/10.1038/nature11005
Publication status	Published - 2012

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Garnett, M. J., Edelman, E. J., Heidorn, S. J., Dastur, A., Lau, K. W., Greninger, P., Thompson, I. R., Luo, X., Soares, J., Liu, Q., Iorio, F., Surdez, D., Chen, L., Milano, R. J., Bignell, G. R., Tam, A. T., Davies, H., Stevenson, J. A., Barthorpe, S., ... Greenman, C. (2012). Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature, 483(7391), 570-575. https://doi.org/10.1038/nature11005

Garnett, Mathew J. ; Edelman, Elena J. ; Heidorn, Sonja J. ; Dastur, Anahita ; Lau, King Wai ; Greninger, Patricia ; Thompson, I. Richard ; Luo, Xi ; Soares, Jorge ; Liu, Qingsong ; Iorio, Francesco ; Surdez, Didier ; Chen, Li ; Milano, Randy J. ; Bignell, Graham R. ; Tam, Ah T. ; Davies, Helen ; Stevenson, Jesse A. ; Barthorpe, Syd ; Lutz, Stephen R. ; Kogera, Fiona ; Lawrence, Karl ; Mclaren-douglas, Anne ; Mitropoulos, Xeni ; Mironenko, Tatiana ; Thi, Helen ; Richardson, Laura ; Zhou, Wenjun ; Jewitt, Frances ; Zhang, Tinghu ; O'Brien, Patrick ; Boisvert, Jessica L. ; Price, Stacey ; Hur, Wooyoung ; Yang, Wanjuan ; Deng, Xianming ; Butler, Adam ; Choi, Hwan Geun ; Chang, Jae Won ; Baselga, Jose ; Stamenkovic, Ivan ; Engelman, Jeffrey A. ; Sharma, Sreenath V. ; Delattre, Olivier ; Saez-rodriguez, Julio ; Gray, Nathanael S. ; Settleman, Jeffrey ; Futreal, P. Andrew ; Haber, Daniel A. ; Stratton, Michael R. ; Ramaswamy, Sridhar ; Mcdermott, Ultan ; Benes, Cyril H. ; Greenman, Christopher. / Systematic identification of genomic markers of drug sensitivity in cancer cells. In: Nature. 2012 ; Vol. 483, No. 7391. pp. 570-575.

@article{7480170c8b654ee3a63e08b1a6679478,

title = "Systematic identification of genomic markers of drug sensitivity in cancer cells",

author = "Garnett, {Mathew J.} and Edelman, {Elena J.} and Heidorn, {Sonja J.} and Anahita Dastur and Lau, {King Wai} and Patricia Greninger and Thompson, {I. Richard} and Xi Luo and Jorge Soares and Qingsong Liu and Francesco Iorio and Didier Surdez and Li Chen and Milano, {Randy J.} and Bignell, {Graham R.} and Tam, {Ah T.} and Helen Davies and Stevenson, {Jesse A.} and Syd Barthorpe and Lutz, {Stephen R.} and Fiona Kogera and Karl Lawrence and Anne Mclaren-douglas and Xeni Mitropoulos and Tatiana Mironenko and Helen Thi and Laura Richardson and Wenjun Zhou and Frances Jewitt and Tinghu Zhang and Patrick O'Brien and Boisvert, {Jessica L.} and Stacey Price and Wooyoung Hur and Wanjuan Yang and Xianming Deng and Adam Butler and Choi, {Hwan Geun} and Chang, {Jae Won} and Jose Baselga and Ivan Stamenkovic and Engelman, {Jeffrey A.} and Sharma, {Sreenath V.} and Olivier Delattre and Julio Saez-rodriguez and Gray, {Nathanael S.} and Jeffrey Settleman and Futreal, {P. Andrew} and Haber, {Daniel A.} and Stratton, {Michael R.} and Sridhar Ramaswamy and Ultan Mcdermott and Benes, {Cyril H.} and Christopher Greenman",

year = "2012",

doi = "10.1038/nature11005",

language = "English",

volume = "483",

pages = "570--575",

journal = "Nature",

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Garnett, MJ, Edelman, EJ, Heidorn, SJ, Dastur, A, Lau, KW, Greninger, P, Thompson, IR, Luo, X, Soares, J, Liu, Q, Iorio, F, Surdez, D, Chen, L, Milano, RJ, Bignell, GR, Tam, AT, Davies, H, Stevenson, JA, Barthorpe, S, Lutz, SR, Kogera, F, Lawrence, K, Mclaren-douglas, A, Mitropoulos, X, Mironenko, T, Thi, H, Richardson, L, Zhou, W, Jewitt, F, Zhang, T, O'Brien, P, Boisvert, JL, Price, S, Hur, W, Yang, W, Deng, X, Butler, A, Choi, HG, Chang, JW, Baselga, J, Stamenkovic, I, Engelman, JA, Sharma, SV, Delattre, O, Saez-rodriguez, J, Gray, NS, Settleman, J, Futreal, PA, Haber, DA, Stratton, MR, Ramaswamy, S, Mcdermott, U, Benes, CH & Greenman, C 2012, 'Systematic identification of genomic markers of drug sensitivity in cancer cells', Nature, vol. 483, no. 7391, pp. 570-575. https://doi.org/10.1038/nature11005

Systematic identification of genomic markers of drug sensitivity in cancer cells. / Garnett, Mathew J.; Edelman, Elena J.; Heidorn, Sonja J.; Dastur, Anahita; Lau, King Wai; Greninger, Patricia; Thompson, I. Richard; Luo, Xi; Soares, Jorge; Liu, Qingsong; Iorio, Francesco; Surdez, Didier; Chen, Li; Milano, Randy J.; Bignell, Graham R.; Tam, Ah T.; Davies, Helen; Stevenson, Jesse A.; Barthorpe, Syd; Lutz, Stephen R.; Kogera, Fiona; Lawrence, Karl; Mclaren-douglas, Anne; Mitropoulos, Xeni; Mironenko, Tatiana; Thi, Helen; Richardson, Laura; Zhou, Wenjun; Jewitt, Frances; Zhang, Tinghu; O'Brien, Patrick; Boisvert, Jessica L.; Price, Stacey; Hur, Wooyoung; Yang, Wanjuan; Deng, Xianming; Butler, Adam; Choi, Hwan Geun; Chang, Jae Won; Baselga, Jose; Stamenkovic, Ivan; Engelman, Jeffrey A.; Sharma, Sreenath V.; Delattre, Olivier; Saez-rodriguez, Julio; Gray, Nathanael S.; Settleman, Jeffrey; Futreal, P. Andrew; Haber, Daniel A.; Stratton, Michael R.; Ramaswamy, Sridhar; Mcdermott, Ultan; Benes, Cyril H.; Greenman, Christopher.

In: Nature, Vol. 483, No. 7391, 2012, p. 570-575.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Systematic identification of genomic markers of drug sensitivity in cancer cells

AU - Garnett, Mathew J.

AU - Edelman, Elena J.

AU - Heidorn, Sonja J.

AU - Dastur, Anahita

AU - Lau, King Wai

AU - Greninger, Patricia

AU - Thompson, I. Richard

AU - Luo, Xi

AU - Soares, Jorge

AU - Liu, Qingsong

AU - Iorio, Francesco

AU - Surdez, Didier

AU - Chen, Li

AU - Milano, Randy J.

AU - Bignell, Graham R.

AU - Tam, Ah T.

AU - Davies, Helen

AU - Stevenson, Jesse A.

AU - Barthorpe, Syd

AU - Lutz, Stephen R.

AU - Kogera, Fiona

AU - Lawrence, Karl

AU - Mclaren-douglas, Anne

AU - Mitropoulos, Xeni

AU - Mironenko, Tatiana

AU - Thi, Helen

AU - Richardson, Laura

AU - Zhou, Wenjun

AU - Jewitt, Frances

AU - Zhang, Tinghu

AU - O'Brien, Patrick

AU - Boisvert, Jessica L.

AU - Price, Stacey

AU - Hur, Wooyoung

AU - Yang, Wanjuan

AU - Deng, Xianming

AU - Butler, Adam

AU - Choi, Hwan Geun

AU - Chang, Jae Won

AU - Baselga, Jose

AU - Stamenkovic, Ivan

AU - Engelman, Jeffrey A.

AU - Sharma, Sreenath V.

AU - Delattre, Olivier

AU - Saez-rodriguez, Julio

AU - Gray, Nathanael S.

AU - Settleman, Jeffrey

AU - Futreal, P. Andrew

AU - Haber, Daniel A.

AU - Stratton, Michael R.

AU - Ramaswamy, Sridhar

AU - Mcdermott, Ultan

AU - Benes, Cyril H.

AU - Greenman, Christopher

PY - 2012

Y1 - 2012

U2 - 10.1038/nature11005

DO - 10.1038/nature11005

M3 - Article

VL - 483

SP - 570

EP - 575

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7391

ER -