Targeting the oncofetal Thomsen-Friedenreich disaccharide using Jacalin-PEG phthalocyanine gold nanoparticles for photodynamic cancer therapy

Girgis Obaid, Isabelle Chambrier, Michael J. Cook, David A. Russell

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)

Abstract

Light-sensitive: Targeted photodynamic therapy is achieved by using gold nanoparticles that are stabilized by a mixed monolayer of a hydrophobic zinc phthalocyanine photosensitizer, which produces cytotoxic singlet oxygen, and a water-soluble thiol-functionalized poly(ethylene glycol) carrying the lectin jacalin, which targets the Thomsen–Friedenreich disaccharide antigen at the surface of cancer cells.
Original languageEnglish
Pages (from-to)6158-6162
Number of pages5
JournalAngewandte Chemie International Edition
Volume51
Issue number25
DOIs
Publication statusPublished - 2012

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