Targeting the oncofetal Thomsen-Friedenreich disaccharide using Jacalin-PEG phthalocyanine gold nanoparticles for photodynamic cancer therapy

Girgis Obaid; Isabelle Chambrier; Michael J. Cook; David A. Russell

doi:10.1002/anie.201201468

Targeting the oncofetal Thomsen-Friedenreich disaccharide using Jacalin-PEG phthalocyanine gold nanoparticles for photodynamic cancer therapy

Girgis Obaid, Isabelle Chambrier, Michael J. Cook, David A. Russell

School of Chemistry

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

Light-sensitive: Targeted photodynamic therapy is achieved by using gold nanoparticles that are stabilized by a mixed monolayer of a hydrophobic zinc phthalocyanine photosensitizer, which produces cytotoxic singlet oxygen, and a water-soluble thiol-functionalized poly(ethylene glycol) carrying the lectin jacalin, which targets the Thomsen–Friedenreich disaccharide antigen at the surface of cancer cells.

Original language	English
Pages (from-to)	6158-6162
Number of pages	5
Journal	Angewandte Chemie International Edition
Volume	51
Issue number	25
DOIs	https://doi.org/10.1002/anie.201201468
Publication status	Published - 2012

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10.1002/anie.201201468

Cite this

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abstract = "Light-sensitive: Targeted photodynamic therapy is achieved by using gold nanoparticles that are stabilized by a mixed monolayer of a hydrophobic zinc phthalocyanine photosensitizer, which produces cytotoxic singlet oxygen, and a water-soluble thiol-functionalized poly(ethylene glycol) carrying the lectin jacalin, which targets the Thomsen–Friedenreich disaccharide antigen at the surface of cancer cells.",

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