Tec family kinases in inflammation and disease

Nicole J Horwood, Ania M Urbaniak, Lynett Danks

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell development and recent evidence showing that blocking Btk signaling is effective in ameliorating lymphoma progression and experimental arthritis. This review will examine the role of TFK in myeloid cell function and the potential of targeting these kinases as a therapeutic intervention in autoimmune disorders such as rheumatoid arthritis.

Original languageEnglish
Pages (from-to)87-103
Number of pages17
JournalMolecular Immunology
Volume31
Issue number2
Early online date26 Mar 2012
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Animals
  • Arthritis, Rheumatoid/drug therapy
  • Autoimmune Diseases/drug therapy
  • Enzyme Inhibitors/therapeutic use
  • Humans
  • Inflammation/metabolism
  • Mice
  • Myeloid Cells/cytology
  • Protein-Tyrosine Kinases/antagonists & inhibitors

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