Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure

Palle B. Jeppesen; Marek Pertkiewicz; Bernard Messing; Kishore Iyer; Douglas L. Seidner; Stephen J. D. O'Keefe; Alastair Forbes; Hartmut Heinze; Bo Joelsson

doi:10.1053/j.gastro.2012.09.007

Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure

Palle B. Jeppesen, Marek Pertkiewicz, Bernard Messing, Kishore Iyer, Douglas L. Seidner, Stephen J. D. O'Keefe, Alastair Forbes, Hartmut Heinze, Bo Joelsson

Research output: Contribution to journal › Article › peer-review

370 Citations (Scopus)

Abstract

Teduglutide, a glucagon-like peptide 2 analogue, might restore intestinal structural and functional integrity by promoting growth of the mucosa and reducing gastric emptying and secretion. These factors could increase fluid and nutrient absorption in patients with short bowel syndrome with intestinal failure (SBS-IF). We performed a prospective study to determine whether teduglutide reduces parenteral support in patients with SBS-IF.

Original language	English
Pages (from-to)	1473-1481.e3
Number of pages	9
Journal	Gastroenterology
Volume	143
Issue number	6
Early online date	11 Sep 2012
DOIs	https://doi.org/10.1053/j.gastro.2012.09.007
Publication status	Published - Dec 2012

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Biological Markers
Citrulline
Dose-Response Relationship, Drug
Double-Blind Method
Endpoint Determination
Female
Humans
Injections, Subcutaneous
Intestinal Absorption
Intestinal Diseases
Intestines
Male
Middle Aged
Parenteral Nutrition
Peptides
Prospective Studies
Short Bowel Syndrome
Treatment Outcome
Video Recording
Young Adult

Access to Document

10.1053/j.gastro.2012.09.007

Cite this

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title = "Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure",

abstract = "Teduglutide, a glucagon-like peptide 2 analogue, might restore intestinal structural and functional integrity by promoting growth of the mucosa and reducing gastric emptying and secretion. These factors could increase fluid and nutrient absorption in patients with short bowel syndrome with intestinal failure (SBS-IF). We performed a prospective study to determine whether teduglutide reduces parenteral support in patients with SBS-IF.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Biological Markers, Citrulline, Dose-Response Relationship, Drug, Double-Blind Method, Endpoint Determination, Female, Humans, Injections, Subcutaneous, Intestinal Absorption, Intestinal Diseases, Intestines, Male, Middle Aged, Parenteral Nutrition, Peptides, Prospective Studies, Short Bowel Syndrome, Treatment Outcome, Video Recording, Young Adult",

author = "Jeppesen, {Palle B.} and Marek Pertkiewicz and Bernard Messing and Kishore Iyer and Seidner, {Douglas L.} and O'Keefe, {Stephen J. D.} and Alastair Forbes and Hartmut Heinze and Bo Joelsson",

year = "2012",

month = dec,

doi = "10.1053/j.gastro.2012.09.007",

language = "English",

volume = "143",

pages = "1473--1481.e3",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "Elsevier",

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Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure. / Jeppesen, Palle B.; Pertkiewicz, Marek; Messing, Bernard; Iyer, Kishore; Seidner, Douglas L.; O'Keefe, Stephen J. D.; Forbes, Alastair; Heinze, Hartmut; Joelsson, Bo.

In: Gastroenterology, Vol. 143, No. 6, 12.2012, p. 1473-1481.e3.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure

AU - Jeppesen, Palle B.

AU - Pertkiewicz, Marek

AU - Messing, Bernard

AU - Iyer, Kishore

AU - Seidner, Douglas L.

AU - O'Keefe, Stephen J. D.

AU - Forbes, Alastair

AU - Heinze, Hartmut

AU - Joelsson, Bo

PY - 2012/12

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AB - Teduglutide, a glucagon-like peptide 2 analogue, might restore intestinal structural and functional integrity by promoting growth of the mucosa and reducing gastric emptying and secretion. These factors could increase fluid and nutrient absorption in patients with short bowel syndrome with intestinal failure (SBS-IF). We performed a prospective study to determine whether teduglutide reduces parenteral support in patients with SBS-IF.

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KW - Aged, 80 and over

KW - Biological Markers

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KW - Endpoint Determination

KW - Female

KW - Humans

KW - Injections, Subcutaneous

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KW - Peptides

KW - Prospective Studies

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KW - Treatment Outcome

KW - Video Recording

KW - Young Adult

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DO - 10.1053/j.gastro.2012.09.007

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VL - 143

SP - 1473-1481.e3

JO - Gastroenterology

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