Temperature-controlled electrospinning of EVOH nanofibre mats encapsulated with Ag, CuO, and ZnO particles for skin wound dressing

Dandan Liu, Chuanwei Zhang, Guirong Dong, Chao Xu, Dianzi Liu, Yuan Lv, Bin Zhong, Bin Wang

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To treat skin burns, a new wound dressing, nanofibre mats with metal or metal oxide nanoparticles (Ag, CuO, and ZnO), was fabricated using the electrospinning technique. During a therapeutic process, the antibacterial ability and bio-compatibility of a new dressing material are of major concern. To expound the characteristics of ethylene vinyl alcohol (EVOH) nanofibre mats encapsulated with metal or metal oxide nanoparticles, denoted as Ag-EVOH, CuO-EVOH, and ZnO-EVOH, for use as new wound dressing materials, we investigated the suitable processing parameters to fabricate these materials, such as the voltage, tip-to-collector distance, concentration of the solution, and effect of environmental temperature. The antibacterial ability and bio-compatibility of Ag-EVOH, CuO-EVOH, and ZnO-EVOH were then tested and quantified. The outcomes show that the most suitable temperature for the fabrication of the materials is 40 °C (±3 °C). The antibacterial experiment results indicate that 0.08 g/ml of metal/metallic oxide shows the highest antibacterial ability toward Staphylococcus aureus. Furthermore, the largest diameters of the bacteriostatic loops of the three types of nanofibre mats, i.e. Ag-EVOH, CuO-EVOH, and ZnO-EVOH, are 5.89, 5.21, and 4.12 mm, respectively. Finally, the cell proliferations on the three nanofibre mats show a similar growth trend.
Original languageEnglish
Article number015007
JournalMaterials Research Express
Issue number1
Early online date26 Sep 2018
Publication statusPublished - Jan 2019


  • antibacterial ability
  • cell proliferation
  • electrospinning
  • nanoparticles
  • temperature

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