Temperature dependence of mucin adsorption

James McColl, Gleb E. Yakubov, Jeremy J. Ramsden

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The kinetics of adsorption and desorption on a silica-like surface of the large glycoprotein mucin have been measured across a range of temperatures from 25 to 60 °C. The area occupied per molecule diminishes with increasing temperature both in the bulk and adsorbed states, implying that the glycoprotein belongs to the “natively open” conformational class. Due to the conformational rearrangement, the specific interaction energy governing desorption greatly increases with temperature, resulting in an impressively regulated temperature-invariant dynamic surface coating.
Original languageEnglish
Pages (from-to)902–905
Number of pages4
Issue number3
Early online date4 Jan 2008
Publication statusPublished - 1 Feb 2008

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