Test-retest reliability of spatial navigation in adults at-risk of Alzheimer’s disease

Gillian Coughlan; Vaisakh Puthusseryppady; Ellen Lowry; Rachel Gillings; Hugo J. Spiers; Anne-Marie Minihane; Michael Hornberger

doi:10.1371/journal.pone.0239077

Test-retest reliability of spatial navigation in adults at-risk of Alzheimer’s disease

Gillian Coughlan, Vaisakh Puthusseryppady, Ellen Lowry, Rachel Gillings, Hugo J. Spiers, Anne-Marie Minihane, Michael Hornberger

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Abstract

The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer‘s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test–retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.

Original language	English
Article number	e0239077
Journal	PLoS One
Volume	15
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0239077
Publication status	Published - 22 Sep 2020

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Accepted_ManuscriptAccepted author manuscript, 372 KBLicence: CC BY
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title = "Test-retest reliability of spatial navigation in adults at-risk of Alzheimer{\textquoteright}s disease",

abstract = "The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer{\textquoteleft}s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test–retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.",

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AU - Spiers, Hugo J.

AU - Minihane, Anne-Marie

AU - Hornberger, Michael

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Test-retest reliability of spatial navigation in adults at-risk of Alzheimer’s disease

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Michael Hornberger

Anne-Marie Minihane

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