The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS

Tom L. Blundell; Risto Lapatto; Andrew F. Wilderspin; Andrew M. Hemmings; Peter M. Hobart; Dennis E. Danley; Peter J. Whittle

doi:10.1016/0968-0004(90)90280-O

The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS

Tom L. Blundell, Risto Lapatto, Andrew F. Wilderspin, Andrew M. Hemmings, Peter M. Hobart, Dennis E. Danley, Peter J. Whittle

Research output: Contribution to journal › Review article › peer-review

90 Citations (Scopus)

Abstract

A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.

Original language	English
Pages (from-to)	425-430
Number of pages	6
Journal	Trends in Biochemical Sciences
Volume	15
Issue number	11
DOIs	https://doi.org/10.1016/0968-0004(90)90280-O
Publication status	Published - Nov 1990
Externally published	Yes

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10.1016/0968-0004(90)90280-O

Cite this

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abstract = "A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.",

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AU - Blundell, Tom L.

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AU - Hemmings, Andrew M.

AU - Hobart, Peter M.

AU - Danley, Dennis E.

AU - Whittle, Peter J.

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AB - A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.

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The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS

Abstract

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