The Addenbrooke's Cognitive Examination Revised (ACE-R): A brief cognitive test battery for dementia screening

Eneida Mioshi, Kate Dawson, Joanna Mitchell, Robert Arnold, John R. Hodges

Research output: Contribution to journalArticle

1233 Citations (Scopus)

Abstract

There is a clear need for brief, but sensitive and specific, cognitive screening instruments as evidenced by the popularity of the Addenbrooke's Cognitive Examination (ACE).

OBJECTIVES: We aimed to validate an improved revision (the ACE-R) which incorporates five sub-domain scores (orientation/attention, memory, verbal fluency, language and visuo-spatial).

METHODS: Standard tests for evaluating dementia screening tests were applied. A total of 241 subjects participated in this study (Alzheimer's disease=67, frontotemporal dementia=55, dementia of Lewy Bodies=20; mild cognitive impairment-MCI=36; controls=63).

RESULTS: Reliability of the ACE-R was very good (alpha coefficient=0.8). Correlation with the Clinical Dementia Scale was significant (r=-0.321, p<0.001). Two cut-offs were defined (88: sensitivity=0.94, specificity=0.89; 82: sensitivity=0.84, specificity=1.0). Likelihood ratios of dementia were generated for scores between 88 and 82: at a cut-off of 82 the likelihood of dementia is 100:1. A comparison of individual age and education matched groups of MCI, AD and controls placed the MCI group performance between controls and AD and revealed MCI patients to be impaired in areas other than memory (attention/orientation, verbal fluency and language).

CONCLUSIONS: The ACE-R accomplishes standards of a valid dementia screening test, sensitive to early cognitive dysfunction.

Original languageEnglish
Pages (from-to)1078-1085
Number of pages8
JournalInternational Journal of Geriatric Psychiatry
Volume21
Issue number11
Early online date15 Sep 2006
DOIs
Publication statusPublished - Nov 2006
Externally publishedYes

Keywords

  • Aged
  • Aged, 80 and over
  • Dementia/diagnosis
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests/standards
  • Psychiatric Status Rating Scales
  • Reproducibility of Results
  • Sensitivity and Specificity

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