The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt

Olorunseun O Ogunwobi, Ian L P Beales

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)

Abstract

Obesity is a major risk factor for the development of colon cancer. Secretion of the hormone leptin from adipocytes is increased in obesity, and serum levels are proportional to body fat mass. Serum leptin levels are an independent risk factor for colon cancer. Leptin receptors are expressed in normal, premalignant and malignant colonic epithelia. We have investigated the effects of leptin on proliferation and apoptosis of colonic cancer cells and the early signalling events involved.
Original languageEnglish
Pages (from-to)401-409
Number of pages9
JournalInternational Journal of Colorectal Disease
Volume22
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Apoptosis
  • Cell Division
  • Cell Line, Tumor
  • Colonic Neoplasms
  • Enzyme Activation
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • JNK Mitogen-Activated Protein Kinases
  • Janus Kinase 2
  • Leptin
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases
  • Proto-Oncogene Proteins c-akt

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