The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt

Olorunseun O Ogunwobi; Ian L P Beales

doi:10.1007/s00384-006-0181-y

The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt

Olorunseun O Ogunwobi, Ian L P Beales

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

Obesity is a major risk factor for the development of colon cancer. Secretion of the hormone leptin from adipocytes is increased in obesity, and serum levels are proportional to body fat mass. Serum leptin levels are an independent risk factor for colon cancer. Leptin receptors are expressed in normal, premalignant and malignant colonic epithelia. We have investigated the effects of leptin on proliferation and apoptosis of colonic cancer cells and the early signalling events involved.

Original language	English
Pages (from-to)	401-409
Number of pages	9
Journal	International Journal of Colorectal Disease
Volume	22
Issue number	4
DOIs	https://doi.org/10.1007/s00384-006-0181-y
Publication status	Published - Apr 2007

Keywords

Apoptosis
Cell Division
Cell Line, Tumor
Colonic Neoplasms
Enzyme Activation
Humans
Intracellular Signaling Peptides and Proteins
JNK Mitogen-Activated Protein Kinases
Janus Kinase 2
Leptin
Phosphatidylinositol 3-Kinases
Phosphotransferases
Proto-Oncogene Proteins c-akt

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00384-006-0181-y

Cite this

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title = "The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt",

abstract = "Obesity is a major risk factor for the development of colon cancer. Secretion of the hormone leptin from adipocytes is increased in obesity, and serum levels are proportional to body fat mass. Serum leptin levels are an independent risk factor for colon cancer. Leptin receptors are expressed in normal, premalignant and malignant colonic epithelia. We have investigated the effects of leptin on proliferation and apoptosis of colonic cancer cells and the early signalling events involved.",

keywords = "Apoptosis, Cell Division, Cell Line, Tumor, Colonic Neoplasms, Enzyme Activation, Humans, Intracellular Signaling Peptides and Proteins, JNK Mitogen-Activated Protein Kinases, Janus Kinase 2, Leptin, Phosphatidylinositol 3-Kinases, Phosphotransferases, Proto-Oncogene Proteins c-akt",

author = "Ogunwobi, {Olorunseun O} and Beales, {Ian L P}",

year = "2007",

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language = "English",

volume = "22",

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journal = "International Journal of Colorectal Disease",

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The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. / Ogunwobi, Olorunseun O; Beales, Ian L P.

In: International Journal of Colorectal Disease, Vol. 22, No. 4, 04.2007, p. 401-409.

Research output: Contribution to journal › Article › peer-review

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AU - Beales, Ian L P

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AB - Obesity is a major risk factor for the development of colon cancer. Secretion of the hormone leptin from adipocytes is increased in obesity, and serum levels are proportional to body fat mass. Serum leptin levels are an independent risk factor for colon cancer. Leptin receptors are expressed in normal, premalignant and malignant colonic epithelia. We have investigated the effects of leptin on proliferation and apoptosis of colonic cancer cells and the early signalling events involved.

KW - Apoptosis

KW - Cell Division

KW - Cell Line, Tumor

KW - Colonic Neoplasms

KW - Enzyme Activation

KW - Humans

KW - Intracellular Signaling Peptides and Proteins

KW - JNK Mitogen-Activated Protein Kinases

KW - Janus Kinase 2

KW - Leptin

KW - Phosphatidylinositol 3-Kinases

KW - Phosphotransferases

KW - Proto-Oncogene Proteins c-akt

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