Abstract
Obesity is a major risk factor for the development of colon cancer. Secretion of the hormone leptin from adipocytes is increased in obesity, and serum levels are proportional to body fat mass. Serum leptin levels are an independent risk factor for colon cancer. Leptin receptors are expressed in normal, premalignant and malignant colonic epithelia. We have investigated the effects of leptin on proliferation and apoptosis of colonic cancer cells and the early signalling events involved.
Original language | English |
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Pages (from-to) | 401-409 |
Number of pages | 9 |
Journal | International Journal of Colorectal Disease |
Volume | 22 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2007 |
Keywords
- Apoptosis
- Cell Division
- Cell Line, Tumor
- Colonic Neoplasms
- Enzyme Activation
- Humans
- Intracellular Signaling Peptides and Proteins
- JNK Mitogen-Activated Protein Kinases
- Janus Kinase 2
- Leptin
- Phosphatidylinositol 3-Kinases
- Phosphotransferases
- Proto-Oncogene Proteins c-akt