The association of age with gastric emptying

N Gainsborough, V L Maskrey, M L Nelson, J Keating, R A Sherwood, S H Jackson, C G Swift

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Gastric emptying is important as a rate-limiting step in the absorption of orally administered drugs. Paracetamol absorption kinetics were used to compare gastric emptying in 19 fit elderly and 19 fit young volunteers. The results showed no significant difference in any of the derived parameters (t1/2abs, tlag and tmax) between the two groups. These results suggest that ageing does not impair this rate-limiting step in drug absorption.
Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalAge and Ageing
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1993

Keywords

  • Acetaminophen
  • Adult
  • Aged
  • Aged 80 and over
  • Aging
  • Female
  • Gastric Emptying
  • Half-Life
  • Humans
  • Intestinal Absorption
  • Male
  • Middle Aged
  • Pilot Projects
  • Reference Values

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