Methods: The analysis was conducted among subjects recruited into the Diagnosis and Classification Criteria in Vasculitis Study (DCAVS). The study captures consecutive patients presenting to clinic-based physicians. New onset blindness was assessed six months after diagnosis by completion of the Vasculitis Damage Index (VDI). Logistic regression analysis was used to assess the association between blindness and clinical variables.
Results: Of 433 patients with GCA from 26 countries, 7.9% presented with blindness in at least one eye at six months. Risk factors identified at baseline for blindness at six months were identified and included prevalent stroke (OR = 4.47, 95% CI: 1.30 to 15.41), and peripheral vascular disease (OR = 10.44, 95% CI: 2.94 to 37.03).
Conclusion: This is the largest study to date of subjects with incident GCA and confirms that blindness remains a common complication of disease and is associated with established vascular disease.
- Giant cell
- Norwich Medical School - Professor of Genetic Epidemiology
- Norwich Institute for Healthy Aging - Member
- Norwich Epidemiology Centre - Member
- Epidemiology and Public Health - Member
- Musculoskeletal Medicine - Member
- Nutrition and Preventive Medicine - Member
- Public Health and Health Services Research - Member
Person: Group Lead, Research Group Member, Research Centre Member, Academic, Teaching & Research