The case for strategic international alliances to harness nutritional genomics for public and personal health

Jim Kaput; Jose M Ordovas; Lynnette Ferguson; Ben van Ommen; Raymond L Rodriguez; Lindsay Allen; Bruce N Ames; Kevin Dawson; Bruce German; Ronald Krauss; Wasyl Malyj; Michael C Archer; Stephen Barnes; Amelia Bartholomew; Ruth Birk; Peter van Bladeren; Kent J Bradford; Kenneth H Brown; Rosane Caetano; David Castle; Ruth Chadwick; Stephen Clarke; Karine Clément; Craig A Cooney; Dolores Corella; Ivana Beatrice Manica da Cruz; Hannelore Daniel; Troy Duster; Sven O E Ebbesson; Ruan Elliott; Susan Fairweather-Tait; Jim Felton; Michael Fenech; John W Finley; Nancy Fogg-Johnson; Rosalynn Gill-Garrison; Michael J Gibney; Peter J Gillies; Jan-Ake Gustafsson; John L Hartman; Lin He; Jae-Kwan Hwang; Jean-Philippe Jais; Yangsoo Jang; Hans Joost; Claudine Junien; Mitchell Kanter; Warren A Kibbe; Berthold Koletzko; Bruce R Korf; Kenneth Kornman; David W Krempin; Dominique Langin; Denis R Lauren; Jong Ho Lee; Gilbert A Leveille; Su-Ju Lin; John Mathers; Michael Mayne; Warren McNabb; John A Milner; Peter Morgan; Michael Muller; Yuri Nikolsky; Frans van der Ouderaa; Taesun Park; Norma Pensel; Francisco Perez-Jimenez; Kaisa Poutanen; Matthew Roberts; Wim H M Saris; Gertrud Schuster; Andrew N Shelling; Artemis P Simopoulos; Sue Southon; E Shyong Tai; Bradford Towne; Paul Trayhurn; Ricardo Uauy; Willard J Visek; Craig Warden; Rick Weiss; John Wiencke; Jack Winkler; George L Wolff; Xi Zhao-Wilson; Jean-Daniel Zucker

doi:10.1079/BJN20051585

The case for strategic international alliances to harness nutritional genomics for public and personal health

Jim Kaput, Jose M Ordovas, Lynnette Ferguson, Ben van Ommen, Raymond L Rodriguez, Lindsay Allen, Bruce N Ames, Kevin Dawson, Bruce German, Ronald Krauss, Wasyl Malyj, Michael C Archer, Stephen Barnes, Amelia Bartholomew, Ruth Birk, Peter van Bladeren, Kent J Bradford, Kenneth H Brown, Rosane Caetano, David CastleRuth Chadwick, Stephen Clarke, Karine Clément, Craig A Cooney, Dolores Corella, Ivana Beatrice Manica da Cruz, Hannelore Daniel, Troy Duster, Sven O E Ebbesson, Ruan Elliott, Susan Fairweather-Tait, Jim Felton, Michael Fenech, John W Finley, Nancy Fogg-Johnson, Rosalynn Gill-Garrison, Michael J Gibney, Peter J Gillies, Jan-Ake Gustafsson, John L Hartman, Lin He, Jae-Kwan Hwang, Jean-Philippe Jais, Yangsoo Jang, Hans Joost, Claudine Junien, Mitchell Kanter, Warren A Kibbe, Berthold Koletzko, Bruce R Korf, Kenneth Kornman, David W Krempin, Dominique Langin, Denis R Lauren, Jong Ho Lee, Gilbert A Leveille, Su-Ju Lin, John Mathers, Michael Mayne, Warren McNabb, John A Milner, Peter Morgan, Michael Muller, Yuri Nikolsky, Frans van der Ouderaa, Taesun Park, Norma Pensel, Francisco Perez-Jimenez, Kaisa Poutanen, Matthew Roberts, Wim H M Saris, Gertrud Schuster, Andrew N Shelling, Artemis P Simopoulos, Sue Southon, E Shyong Tai, Bradford Towne, Paul Trayhurn, Ricardo Uauy, Willard J Visek, Craig Warden, Rick Weiss, John Wiencke, Jack Winkler, George L Wolff, Xi Zhao-Wilson, Jean-Daniel Zucker

Research output: Contribution to journal › Article › peer-review

134 Citations (Scopus)

Abstract

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

Original language	English
Pages (from-to)	623-632
Number of pages	10
Journal	British Journal of Nutrition
Volume	94
Issue number	5
DOIs	https://doi.org/10.1079/BJN20051585
Publication status	Published - Nov 2005

Keywords

Animals
Disease Models, Animal
Eating
Environment
Genetic Variation
Genome, Human
Genomics
Humans
International Cooperation
Nutritional Physiological Phenomena
Phenotype
Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1079/BJN20051585

Cite this

Kaput, J., Ordovas, J. M., Ferguson, L., van Ommen, B., Rodriguez, R. L., Allen, L., Ames, B. N., Dawson, K., German, B., Krauss, R., Malyj, W., Archer, M. C., Barnes, S., Bartholomew, A., Birk, R., van Bladeren, P., Bradford, K. J., Brown, K. H., Caetano, R., ... Zucker, J.-D. (2005). The case for strategic international alliances to harness nutritional genomics for public and personal health. British Journal of Nutrition, 94(5), 623-632. https://doi.org/10.1079/BJN20051585

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title = "The case for strategic international alliances to harness nutritional genomics for public and personal health",

abstract = "Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.",

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author = "Jim Kaput and Ordovas, {Jose M} and Lynnette Ferguson and {van Ommen}, Ben and Rodriguez, {Raymond L} and Lindsay Allen and Ames, {Bruce N} and Kevin Dawson and Bruce German and Ronald Krauss and Wasyl Malyj and Archer, {Michael C} and Stephen Barnes and Amelia Bartholomew and Ruth Birk and {van Bladeren}, Peter and Bradford, {Kent J} and Brown, {Kenneth H} and Rosane Caetano and David Castle and Ruth Chadwick and Stephen Clarke and Karine Cl{\'e}ment and Cooney, {Craig A} and Dolores Corella and {Manica da Cruz}, {Ivana Beatrice} and Hannelore Daniel and Troy Duster and Ebbesson, {Sven O E} and Ruan Elliott and Susan Fairweather-Tait and Jim Felton and Michael Fenech and Finley, {John W} and Nancy Fogg-Johnson and Rosalynn Gill-Garrison and Gibney, {Michael J} and Gillies, {Peter J} and Jan-Ake Gustafsson and Hartman, {John L} and Lin He and Jae-Kwan Hwang and Jean-Philippe Jais and Yangsoo Jang and Hans Joost and Claudine Junien and Mitchell Kanter and Kibbe, {Warren A} and Berthold Koletzko and Korf, {Bruce R} and Kenneth Kornman and Krempin, {David W} and Dominique Langin and Lauren, {Denis R} and {Ho Lee}, Jong and Leveille, {Gilbert A} and Su-Ju Lin and John Mathers and Michael Mayne and Warren McNabb and Milner, {John A} and Peter Morgan and Michael Muller and Yuri Nikolsky and {van der Ouderaa}, Frans and Taesun Park and Norma Pensel and Francisco Perez-Jimenez and Kaisa Poutanen and Matthew Roberts and Saris, {Wim H M} and Gertrud Schuster and Shelling, {Andrew N} and Simopoulos, {Artemis P} and Sue Southon and Tai, {E Shyong} and Bradford Towne and Paul Trayhurn and Ricardo Uauy and Visek, {Willard J} and Craig Warden and Rick Weiss and John Wiencke and Jack Winkler and Wolff, {George L} and Xi Zhao-Wilson and Jean-Daniel Zucker",

year = "2005",

month = nov,

doi = "10.1079/BJN20051585",

language = "English",

volume = "94",

pages = "623--632",

journal = "British Journal of Nutrition",

issn = "0007-1145",

publisher = "Cambridge University Press",

number = "5",

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Kaput, J, Ordovas, JM, Ferguson, L, van Ommen, B, Rodriguez, RL, Allen, L, Ames, BN, Dawson, K, German, B, Krauss, R, Malyj, W, Archer, MC, Barnes, S, Bartholomew, A, Birk, R, van Bladeren, P, Bradford, KJ, Brown, KH, Caetano, R, Castle, D, Chadwick, R, Clarke, S, Clément, K, Cooney, CA, Corella, D, Manica da Cruz, IB, Daniel, H, Duster, T, Ebbesson, SOE, Elliott, R, Fairweather-Tait, S, Felton, J, Fenech, M, Finley, JW, Fogg-Johnson, N, Gill-Garrison, R, Gibney, MJ, Gillies, PJ, Gustafsson, J-A, Hartman, JL, He, L, Hwang, J-K, Jais, J-P, Jang, Y, Joost, H, Junien, C, Kanter, M, Kibbe, WA, Koletzko, B, Korf, BR, Kornman, K, Krempin, DW, Langin, D, Lauren, DR, Ho Lee, J, Leveille, GA, Lin, S-J, Mathers, J, Mayne, M, McNabb, W, Milner, JA, Morgan, P, Muller, M, Nikolsky, Y, van der Ouderaa, F, Park, T, Pensel, N, Perez-Jimenez, F, Poutanen, K, Roberts, M, Saris, WHM, Schuster, G, Shelling, AN, Simopoulos, AP, Southon, S, Tai, ES, Towne, B, Trayhurn, P, Uauy, R, Visek, WJ, Warden, C, Weiss, R, Wiencke, J, Winkler, J, Wolff, GL, Zhao-Wilson, X & Zucker, J-D 2005, 'The case for strategic international alliances to harness nutritional genomics for public and personal health', British Journal of Nutrition, vol. 94, no. 5, pp. 623-632. https://doi.org/10.1079/BJN20051585

TY - JOUR

T1 - The case for strategic international alliances to harness nutritional genomics for public and personal health

AU - Kaput, Jim

AU - Ordovas, Jose M

AU - Ferguson, Lynnette

AU - van Ommen, Ben

AU - Rodriguez, Raymond L

AU - Allen, Lindsay

AU - Ames, Bruce N

AU - Dawson, Kevin

AU - German, Bruce

AU - Krauss, Ronald

AU - Malyj, Wasyl

AU - Archer, Michael C

AU - Barnes, Stephen

AU - Bartholomew, Amelia

AU - Birk, Ruth

AU - van Bladeren, Peter

AU - Bradford, Kent J

AU - Brown, Kenneth H

AU - Caetano, Rosane

AU - Castle, David

AU - Chadwick, Ruth

AU - Clarke, Stephen

AU - Clément, Karine

AU - Cooney, Craig A

AU - Corella, Dolores

AU - Manica da Cruz, Ivana Beatrice

AU - Daniel, Hannelore

AU - Duster, Troy

AU - Ebbesson, Sven O E

AU - Elliott, Ruan

AU - Fairweather-Tait, Susan

AU - Felton, Jim

AU - Fenech, Michael

AU - Finley, John W

AU - Fogg-Johnson, Nancy

AU - Gill-Garrison, Rosalynn

AU - Gibney, Michael J

AU - Gillies, Peter J

AU - Gustafsson, Jan-Ake

AU - Hartman, John L

AU - He, Lin

AU - Hwang, Jae-Kwan

AU - Jais, Jean-Philippe

AU - Jang, Yangsoo

AU - Joost, Hans

AU - Junien, Claudine

AU - Kanter, Mitchell

AU - Kibbe, Warren A

AU - Koletzko, Berthold

AU - Korf, Bruce R

AU - Kornman, Kenneth

AU - Krempin, David W

AU - Langin, Dominique

AU - Lauren, Denis R

AU - Ho Lee, Jong

AU - Leveille, Gilbert A

AU - Lin, Su-Ju

AU - Mathers, John

AU - Mayne, Michael

AU - McNabb, Warren

AU - Milner, John A

AU - Morgan, Peter

AU - Muller, Michael

AU - Nikolsky, Yuri

AU - van der Ouderaa, Frans

AU - Park, Taesun

AU - Pensel, Norma

AU - Perez-Jimenez, Francisco

AU - Poutanen, Kaisa

AU - Roberts, Matthew

AU - Saris, Wim H M

AU - Schuster, Gertrud

AU - Shelling, Andrew N

AU - Simopoulos, Artemis P

AU - Southon, Sue

AU - Tai, E Shyong

AU - Towne, Bradford

AU - Trayhurn, Paul

AU - Uauy, Ricardo

AU - Visek, Willard J

AU - Warden, Craig

AU - Weiss, Rick

AU - Wiencke, John

AU - Winkler, Jack

AU - Wolff, George L

AU - Zhao-Wilson, Xi

AU - Zucker, Jean-Daniel

PY - 2005/11

Y1 - 2005/11

N2 - Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

AB - Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

KW - Animals

KW - Disease Models, Animal

KW - Eating

KW - Environment

KW - Genetic Variation

KW - Genome, Human

KW - Genomics

KW - Humans

KW - International Cooperation

KW - Nutritional Physiological Phenomena

KW - Phenotype

KW - Research

U2 - 10.1079/BJN20051585

DO - 10.1079/BJN20051585

M3 - Article

C2 - 16277761

SN - 0007-1145

VL - 94

SP - 623

EP - 632

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 5

ER -