The chromosome cycle: coordinating replication and segregation

J. Julian Blow; Tomoyuki U. Tanaka

doi:10.1038/sj.embor.7400557

The chromosome cycle: coordinating replication and segregation

J. Julian Blow, Tomoyuki U. Tanaka

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

Original language	English
Pages (from-to)	1028-1034
Number of pages	7
Journal	EMBO Reports
Volume	6
Issue number	11
DOIs	https://doi.org/10.1038/sj.embor.7400557
Publication status	Published - 1 Nov 2005

Keywords

Cell cycle
Cohesion
DNA replication
Replication licensing

Access to Document

10.1038/sj.embor.7400557

Cite this

@article{b21f4edfc3654391babefe78a3ed1ed4,

title = "The chromosome cycle: coordinating replication and segregation",

abstract = "During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.",

keywords = "Cell cycle, Cohesion, DNA replication, Replication licensing",

author = "Blow, {J. Julian} and Tanaka, {Tomoyuki U.}",

note = "Second in the Cycles review series",

year = "2005",

month = nov,

day = "1",

doi = "10.1038/sj.embor.7400557",

language = "English",

volume = "6",

pages = "1028--1034",

journal = "EMBO Reports",

issn = "1469-221X",

publisher = "EMBO Press",

number = "11",

}

TY - JOUR

T1 - The chromosome cycle: coordinating replication and segregation

AU - Blow, J. Julian

AU - Tanaka, Tomoyuki U.

N1 - Second in the Cycles review series

PY - 2005/11/1

Y1 - 2005/11/1

N2 - During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

AB - During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

KW - Cell cycle

KW - Cohesion

KW - DNA replication

KW - Replication licensing

U2 - 10.1038/sj.embor.7400557

DO - 10.1038/sj.embor.7400557

M3 - Article

VL - 6

SP - 1028

EP - 1034

JO - EMBO Reports

JF - EMBO Reports

SN - 1469-221X

IS - 11

ER -