The chromosome cycle: coordinating replication and segregation

J. Julian Blow, Tomoyuki U. Tanaka

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43 Citations (Scopus)


During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.
Original languageEnglish
Pages (from-to)1028-1034
Number of pages7
JournalEMBO Reports
Issue number11
Publication statusPublished - 1 Nov 2005


  • Cell cycle
  • Cohesion
  • DNA replication
  • Replication licensing

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