The contribution of diet and genotype to iron status in women: a classical twin study

Susan J Fairweather-Tait; Geoffrey R Guile; Ana M Valdes; Anna A Wawer; Rachel Hurst; Jane Skinner; Alexander J Macgregor

doi:10.1371/journal.pone.0083047

The contribution of diet and genotype to iron status in women: a classical twin study

Susan J Fairweather-Tait, Geoffrey R Guile, Ana M Valdes, Anna A Wawer, Rachel Hurst, Jane Skinner, Alexander J Macgregor

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Abstract

This is the first published report examining the combined effect of diet and genotype on body iron content using a classical twin study design. The aim of this study was to determine the relative contribution of genetic and environmental factors in determining iron status. The population was comprised of 200 BMI- and age-matched pairs of MZ and DZ healthy twins, characterised for habitual diet and 15 iron-related candidate genetic markers. Variance components analysis demonstrated that the heritability of serum ferritin (SF) and soluble transferrin receptor was 44% and 54% respectively. Measured single nucleotide polymorphisms explained 5% and selected dietary factors 6% of the variance in iron status; there was a negative association between calcium intake and body iron (p = 0.02) and SF (p = 0.04).

Original language	English
Article number	e83047
Journal	PLoS One
Volume	8
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0083047
Publication status	Published - 31 Dec 2013

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F-T_etal_plone_2013
© 2013 Fairweather-Tait et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Enhancing delivery of minerals using multifunctional carriers.
Fairweather-Tait, S., Parker (IFR), R. & Wilde, P.
Biotechnology and Biological Sciences Research Council
1/04/09 → 31/12/12
Project: Research

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title = "The contribution of diet and genotype to iron status in women: a classical twin study",

abstract = "This is the first published report examining the combined effect of diet and genotype on body iron content using a classical twin study design. The aim of this study was to determine the relative contribution of genetic and environmental factors in determining iron status. The population was comprised of 200 BMI- and age-matched pairs of MZ and DZ healthy twins, characterised for habitual diet and 15 iron-related candidate genetic markers. Variance components analysis demonstrated that the heritability of serum ferritin (SF) and soluble transferrin receptor was 44% and 54% respectively. Measured single nucleotide polymorphisms explained 5% and selected dietary factors 6% of the variance in iron status; there was a negative association between calcium intake and body iron (p = 0.02) and SF (p = 0.04).",

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AU - Skinner, Jane

AU - Macgregor, Alexander J

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The contribution of diet and genotype to iron status in women: a classical twin study

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Enhancing delivery of minerals using multifunctional carriers.

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