The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency

L M Evans; J S Davies; R A Anderson; G R Ellis; S K Jackson; M J Lewis; M P Frenneaux; A Rees; M F Scanlon

The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency

L M Evans, J S Davies, R A Anderson, G R Ellis, S K Jackson, M J Lewis, M P Frenneaux, A Rees, M F Scanlon

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

Abstract

Controversy persists with regard to the atherogenic risk associated with adult growth hormone deficiency (GHD). Endothelial dysfunction and enhanced oxidative stress are early features of atherogenesis. Therefore, we have studied the effect of three months of low dose GH replacement therapy (0.03IU/kg/day) on these parameters in GHD adults.

Original language	English
Pages (from-to)	254-262
Number of pages	9
Journal	European Journal of Endocrinology
Volume	142
Issue number	3
Publication status	Published - Mar 2000

Keywords

Adult
Blood Flow Velocity
Blood Pressure
Case-Control Studies
Endothelium, Vascular
Female
Free Radicals
Growth Hormone
Humans
Hypopituitarism
Male
Middle Aged
Oxidative Stress
Time Factors
Treatment Outcome

Access to Document

https://eje.bioscientifica.com/view/journals/eje/142/3/254.xml

Cite this

Evans, L. M., Davies, J. S., Anderson, R. A., Ellis, G. R., Jackson, S. K., Lewis, M. J., Frenneaux, M. P., Rees, A., & Scanlon, M. F. (2000). The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency. European Journal of Endocrinology, 142(3), 254-262. https://eje.bioscientifica.com/view/journals/eje/142/3/254.xml

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AU - Evans, L M

AU - Davies, J S

AU - Anderson, R A

AU - Ellis, G R

AU - Jackson, S K

AU - Lewis, M J

AU - Frenneaux, M P

AU - Rees, A

AU - Scanlon, M F

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KW - Adult

KW - Blood Flow Velocity

KW - Blood Pressure

KW - Case-Control Studies

KW - Endothelium, Vascular

KW - Female

KW - Free Radicals

KW - Growth Hormone

KW - Humans

KW - Hypopituitarism

KW - Male

KW - Middle Aged

KW - Oxidative Stress

KW - Time Factors

KW - Treatment Outcome

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