The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency

L M Evans, J S Davies, R A Anderson, G R Ellis, S K Jackson, M J Lewis, M P Frenneaux, A Rees, M F Scanlon

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Abstract

Controversy persists with regard to the atherogenic risk associated with adult growth hormone deficiency (GHD). Endothelial dysfunction and enhanced oxidative stress are early features of atherogenesis. Therefore, we have studied the effect of three months of low dose GH replacement therapy (0.03IU/kg/day) on these parameters in GHD adults.
Original languageEnglish
Pages (from-to)254-262
Number of pages9
JournalEuropean Journal of Endocrinology
Volume142
Issue number3
Publication statusPublished - Mar 2000

Keywords

  • Adult
  • Blood Flow Velocity
  • Blood Pressure
  • Case-Control Studies
  • Endothelium, Vascular
  • Female
  • Free Radicals
  • Growth Hormone
  • Humans
  • Hypopituitarism
  • Male
  • Middle Aged
  • Oxidative Stress
  • Time Factors
  • Treatment Outcome

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