The effect of oxidative damage on the calpain proteases in cultured ovine lens

J.D. Morton; J Sanderson; H.Y.Y. Lee; L.J.G. Robertson; K. Gately

The effect of oxidative damage on the calpain proteases in cultured ovine lens

J.D. Morton, J Sanderson, H.Y.Y. Lee, L.J.G. Robertson, K. Gately

Research output: Contribution to journal › Abstract

Abstract

A line of sheep at Lincoln University inherits cataracts and provides a unique opportunity to investigate the role of calpain in cataract formation. The sheep lens culture system has been developed as an alternative, controlled model of cataract formation allowing the measurement of early changes in cataractogenesis and to test the efficacy of calpain inhibitors in preventing cataracts. The purpose of this experiment was to determine which calpain isoforms were present in the cultured lenses and whether oxidative damage led to changes in the amount and type of calpain isoforms.

Original language	English
Pages (from-to)	314
Journal	Investigative Ophthalmology and Visual Science
Volume	44
Issue number	13
Publication status	Published - May 2003

Cite this

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title = "The effect of oxidative damage on the calpain proteases in cultured ovine lens",

abstract = "A line of sheep at Lincoln University inherits cataracts and provides a unique opportunity to investigate the role of calpain in cataract formation. The sheep lens culture system has been developed as an alternative, controlled model of cataract formation allowing the measurement of early changes in cataractogenesis and to test the efficacy of calpain inhibitors in preventing cataracts. The purpose of this experiment was to determine which calpain isoforms were present in the cultured lenses and whether oxidative damage led to changes in the amount and type of calpain isoforms.",

author = "J.D. Morton and J Sanderson and H.Y.Y. Lee and L.J.G. Robertson and K. Gately",

year = "2003",

month = may,

language = "English",

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TY - JOUR

T1 - The effect of oxidative damage on the calpain proteases in cultured ovine lens

AU - Morton, J.D.

AU - Sanderson, J

AU - Lee, H.Y.Y.

AU - Robertson, L.J.G.

AU - Gately, K.

PY - 2003/5

Y1 - 2003/5

N2 - A line of sheep at Lincoln University inherits cataracts and provides a unique opportunity to investigate the role of calpain in cataract formation. The sheep lens culture system has been developed as an alternative, controlled model of cataract formation allowing the measurement of early changes in cataractogenesis and to test the efficacy of calpain inhibitors in preventing cataracts. The purpose of this experiment was to determine which calpain isoforms were present in the cultured lenses and whether oxidative damage led to changes in the amount and type of calpain isoforms.

AB - A line of sheep at Lincoln University inherits cataracts and provides a unique opportunity to investigate the role of calpain in cataract formation. The sheep lens culture system has been developed as an alternative, controlled model of cataract formation allowing the measurement of early changes in cataractogenesis and to test the efficacy of calpain inhibitors in preventing cataracts. The purpose of this experiment was to determine which calpain isoforms were present in the cultured lenses and whether oxidative damage led to changes in the amount and type of calpain isoforms.

M3 - Abstract

VL - 44

SP - 314

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 13

ER -