The effect of perhexiline on myocardial protection during coronary artery surgery: A two-centre, randomized, double-blind, placebo-controlled trial

Nigel E. Drury, Neil J. Howell, Melanie J. Calvert, Ralf J. M. Weber, Eshan L. Senanayake, Michael E. Lewis, Jonathan A. J. Hyde, David H. Green, Jorge G. Mascaro, Ian C. Wilson, Timothy R. Graham, Stephen J. Rooney, Mark R. Viant, Nick Freemantle, Michael P. Frenneaux, Domenico Pagano, investigators

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Perhexiline is thought to modulate metabolism by inhibiting mitochondrial carnitine palmitoyltransferase-1, reducing fatty acid uptake and increasing carbohydrate utilization. This study assessed whether preoperative perhexiline improves markers of myocardial protection in patients undergoing coronary artery bypass graft surgery and analysed its effect on the myocardial metabolome.
Original languageEnglish
Pages (from-to)464-472
Number of pages9
JournalEuropean Journal of Cardio-Thoracic Surgery
Issue number3
Early online date19 Jun 2014
Publication statusPublished - Mar 2015

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