TY - JOUR
T1 - The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: A randomised controlled trial
AU - Arden, Nigel K.
AU - Cro, Suzie
AU - Sheard, Sally
AU - Doré, Caroline J.
AU - Bara, Anna
AU - Tebbs, Susan A.
AU - Hunter, David J.
AU - James, Samuel
AU - Cooper, Cyrus
AU - O'Neill, Terence W.
AU - Macgregor, Alexander
AU - Birrell, Fraser
AU - Keen, Richard
N1 - Data sharing statement: Anonymised patient level data and statistical code available from the corresponding author.
Funding information: Funding was received from Arthritis Research Campaign (now Arthritis Research UK, grant number
K0576). Additional support was received from the National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, University of Oxford (grant number HFRWGQ00 task HF00.EA BRU). Researchers were independent from funders and sponsors. The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.
PY - 2016/11
Y1 - 2016/11
N2 - OBJECTIVE: Epidemiological data suggest low serum 25-hydroxyvitamin D3 (25-OH-D3) levels are associated with radiological progression of knee osteoarthritis (OA). This study aimed to assess whether vitamin D supplementation can slow the rate of progression. METHOD: A 3 year, double-blind, randomised, placebo-controlled trial of 474 patients aged over 50 with radiographically evident knee OA comparing 800 IU cholecalciferol daily with placebo. Primary outcome was difference in rate of medial joint space narrowing (JSN). Secondary outcomes included lateral JSN, Kellgren and Lawrence grade, WOMAC pain, function, stiffness and the Get up and Go test. RESULTS: Vitamin D supplementation increased 25-OH-D3 from an average of 20·7 (SD 8·9) μg/L to 30·4 (SD 7·7) μg/L, compared to 20·7 (SD 8·1) μg/L and 20·3 (SD 8·1) μg/L in the placebo group. There was no significant difference in the rate of JSN over three years in the medial compartment of the index knee between the treatment group (average -0.01 mm/year) and placebo group (-0.08 mm/year), average difference 0.08 mm/year, (95% CI [-0·14 to 0·29], p=0.49). No significant interaction was found between baseline vitamin D levels and treatment effect. There were no significant differences for any of the secondary outcome measures. CONCLUSION: Vitamin D supplementation did not slow the rate of JSN or lead to reduced pain, stiffness or functional loss over a three year period. On the basis of these findings we consider that vitamin D supplementation has no role in the management of knee OA.
AB - OBJECTIVE: Epidemiological data suggest low serum 25-hydroxyvitamin D3 (25-OH-D3) levels are associated with radiological progression of knee osteoarthritis (OA). This study aimed to assess whether vitamin D supplementation can slow the rate of progression. METHOD: A 3 year, double-blind, randomised, placebo-controlled trial of 474 patients aged over 50 with radiographically evident knee OA comparing 800 IU cholecalciferol daily with placebo. Primary outcome was difference in rate of medial joint space narrowing (JSN). Secondary outcomes included lateral JSN, Kellgren and Lawrence grade, WOMAC pain, function, stiffness and the Get up and Go test. RESULTS: Vitamin D supplementation increased 25-OH-D3 from an average of 20·7 (SD 8·9) μg/L to 30·4 (SD 7·7) μg/L, compared to 20·7 (SD 8·1) μg/L and 20·3 (SD 8·1) μg/L in the placebo group. There was no significant difference in the rate of JSN over three years in the medial compartment of the index knee between the treatment group (average -0.01 mm/year) and placebo group (-0.08 mm/year), average difference 0.08 mm/year, (95% CI [-0·14 to 0·29], p=0.49). No significant interaction was found between baseline vitamin D levels and treatment effect. There were no significant differences for any of the secondary outcome measures. CONCLUSION: Vitamin D supplementation did not slow the rate of JSN or lead to reduced pain, stiffness or functional loss over a three year period. On the basis of these findings we consider that vitamin D supplementation has no role in the management of knee OA.
KW - Vitamin D
KW - Knee
KW - Randomised placebo-controlled trial
KW - Osteoarthritis
U2 - 10.1016/j.joca.2016.05.020
DO - 10.1016/j.joca.2016.05.020
M3 - Article
C2 - 27264058
SN - 1063-4584
VL - 24
SP - 1858
EP - 1866
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 11
ER -