The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

B Mihaylova, J Emberson, L Blackwell, A Keech, J Simes, E H Barnes, M Voysey, A Gray, R Collins, C Baigent, Cholesterol Treatment Trialists' (CTT) Collaborators

Research output: Contribution to journalArticlepeer-review

2219 Citations (Scopus)


Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain.
Original languageEnglish
Pages (from-to)581-590
Number of pages10
Issue number9841
Publication statusPublished - 11 Aug 2012


  • Randomized Controlled Trials as Topic
  • Humans
  • Vascular Diseases
  • Treatment Outcome
  • Practice Guidelines as Topic
  • Cholesterol, LDL
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Risk Assessment

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