The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

B Mihaylova, J Emberson, L Blackwell, A Keech, J Simes, E H Barnes, M Voysey, A Gray, R Collins, C Baigent, Cholesterol Treatment Trialists' (CTT) Collaborators

Research output: Contribution to journalArticle

1730 Citations (Scopus)

Abstract

Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain.
Original languageEnglish
Pages (from-to)581-590
Number of pages10
JournalLancet
Volume380
Issue number9841
DOIs
Publication statusPublished - 11 Aug 2012

Keywords

  • Randomized Controlled Trials as Topic
  • Humans
  • Vascular Diseases
  • Treatment Outcome
  • Practice Guidelines as Topic
  • Cholesterol, LDL
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Risk Assessment

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