The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

B Mihaylova; J Emberson; L Blackwell; A Keech; J Simes; E H Barnes; M Voysey; A Gray; R Collins; C Baigent; Cholesterol Treatment Trialists' (CTT) Collaborators

doi:10.1016/S0140-6736(12)60367-5

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

B Mihaylova, J Emberson, L Blackwell, A Keech, J Simes, E H Barnes, M Voysey, A Gray, R Collins, C Baigent, Cholesterol Treatment Trialists' (CTT) Collaborators

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

2472 Citations (Scopus)

Abstract

Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain.

Original language	English
Pages (from-to)	581-590
Number of pages	10
Journal	Lancet
Volume	380
Issue number	9841
DOIs	https://doi.org/10.1016/S0140-6736(12)60367-5
Publication status	Published - 11 Aug 2012

Keywords

Randomized Controlled Trials as Topic
Humans
Vascular Diseases
Treatment Outcome
Practice Guidelines as Topic
Cholesterol, LDL
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Risk Assessment

Access to Document

10.1016/S0140-6736(12)60367-5Licence: Unspecified

Cite this

Mihaylova, B., Emberson, J., Blackwell, L., Keech, A., Simes, J., Barnes, E. H., Voysey, M., Gray, A., Collins, R., Baigent, C., & Cholesterol Treatment Trialists' (CTT) Collaborators (2012). The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet, 380(9841), 581-590. https://doi.org/10.1016/S0140-6736(12)60367-5

@article{bf091ebbddd24cf7bbda2642385787d6,

title = "The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials",

abstract = "Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain.",

keywords = "Randomized Controlled Trials as Topic, Humans, Vascular Diseases, Treatment Outcome, Practice Guidelines as Topic, Cholesterol, LDL, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Risk Assessment",

author = "B Mihaylova and J Emberson and L Blackwell and A Keech and J Simes and Barnes, {E H} and M Voysey and A Gray and R Collins and C Baigent and {Cholesterol Treatment Trialists' (CTT) Collaborators}",

year = "2012",

month = aug,

day = "11",

doi = "10.1016/S0140-6736(12)60367-5",

language = "English",

volume = "380",

pages = "581--590",

journal = "Lancet",

issn = "1474-547X",

publisher = "Elsevier",

number = "9841",

}

Mihaylova, B, Emberson, J, Blackwell, L, Keech, A, Simes, J, Barnes, EH, Voysey, M, Gray, A, Collins, R, Baigent, C & Cholesterol Treatment Trialists' (CTT) Collaborators 2012, 'The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials', Lancet, vol. 380, no. 9841, pp. 581-590. https://doi.org/10.1016/S0140-6736(12)60367-5

TY - JOUR

T1 - The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease

T2 - meta-analysis of individual data from 27 randomised trials

AU - Mihaylova, B

AU - Emberson, J

AU - Blackwell, L

AU - Keech, A

AU - Simes, J

AU - Barnes, E H

AU - Voysey, M

AU - Gray, A

AU - Collins, R

AU - Baigent, C

AU - Cholesterol Treatment Trialists' (CTT) Collaborators

PY - 2012/8/11

Y1 - 2012/8/11

N2 - Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain.

AB - Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain.

KW - Randomized Controlled Trials as Topic

KW - Humans

KW - Vascular Diseases

KW - Treatment Outcome

KW - Practice Guidelines as Topic

KW - Cholesterol, LDL

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors

KW - Risk Assessment

U2 - 10.1016/S0140-6736(12)60367-5

DO - 10.1016/S0140-6736(12)60367-5

M3 - Article

C2 - 22607822

SN - 1474-547X

VL - 380

SP - 581

EP - 590

JO - Lancet

JF - Lancet

IS - 9841

ER -