The emerging NDM carbapenemases

Patrice Nordmann; Laurent Poirel; Timothy R Walsh; David M Livermore

doi:10.1016/j.tim.2011.09.005

The emerging NDM carbapenemases

Patrice Nordmann, Laurent Poirel, Timothy R Walsh, David M Livermore

Research output: Contribution to journal › Article › peer-review

531 Citations (Scopus)

Abstract

Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian subcontinent, where they occur widely in hospital and community infections, and also in contaminated urban water. The main type is NDM-1, but minor variants occur. NDM enzymes are present largely in Enterobacteriaceae, but also in non-fermenters and Vibrionaceae. Dissemination predominantly involves transfer of the blaNDM-1 gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial.

Original language	English
Pages (from-to)	588-95
Number of pages	8
Journal	Trends in Microbiology
Volume	19
Issue number	12
DOIs	https://doi.org/10.1016/j.tim.2011.09.005
Publication status	Published - Dec 2011

Keywords

Bacterial Proteins
Carbapenems
Disease Outbreaks
Enterobacteriaceae
Gene Transfer, Horizontal
Gram-Negative Bacterial Infections
Humans
Plasmids
Pseudomonas
Vibrionaceae
beta-Lactam Resistance
beta-Lactamases

Access to Document

10.1016/j.tim.2011.09.005

Cite this

@article{f083c2e6d7df4906b723fcbc21d833c1,

title = "The emerging NDM carbapenemases",

abstract = "Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian subcontinent, where they occur widely in hospital and community infections, and also in contaminated urban water. The main type is NDM-1, but minor variants occur. NDM enzymes are present largely in Enterobacteriaceae, but also in non-fermenters and Vibrionaceae. Dissemination predominantly involves transfer of the blaNDM-1 gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial.",

keywords = "Bacterial Proteins, Carbapenems, Disease Outbreaks, Enterobacteriaceae, Gene Transfer, Horizontal, Gram-Negative Bacterial Infections, Humans, Plasmids, Pseudomonas, Vibrionaceae, beta-Lactam Resistance, beta-Lactamases",

author = "Patrice Nordmann and Laurent Poirel and Walsh, {Timothy R} and Livermore, {David M}",

year = "2011",

month = dec,

doi = "10.1016/j.tim.2011.09.005",

language = "English",

volume = "19",

pages = "588--95",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier",

number = "12",

}

TY - JOUR

T1 - The emerging NDM carbapenemases

AU - Nordmann, Patrice

AU - Poirel, Laurent

AU - Walsh, Timothy R

AU - Livermore, David M

PY - 2011/12

Y1 - 2011/12

N2 - Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian subcontinent, where they occur widely in hospital and community infections, and also in contaminated urban water. The main type is NDM-1, but minor variants occur. NDM enzymes are present largely in Enterobacteriaceae, but also in non-fermenters and Vibrionaceae. Dissemination predominantly involves transfer of the blaNDM-1 gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial.

AB - Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian subcontinent, where they occur widely in hospital and community infections, and also in contaminated urban water. The main type is NDM-1, but minor variants occur. NDM enzymes are present largely in Enterobacteriaceae, but also in non-fermenters and Vibrionaceae. Dissemination predominantly involves transfer of the blaNDM-1 gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial.

KW - Bacterial Proteins

KW - Carbapenems

KW - Disease Outbreaks

KW - Enterobacteriaceae

KW - Gene Transfer, Horizontal

KW - Gram-Negative Bacterial Infections

KW - Humans

KW - Plasmids

KW - Pseudomonas

KW - Vibrionaceae

KW - beta-Lactam Resistance

KW - beta-Lactamases

U2 - 10.1016/j.tim.2011.09.005

DO - 10.1016/j.tim.2011.09.005

M3 - Article

C2 - 22078325

VL - 19

SP - 588

EP - 595

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 12

ER -