The location determinants of US FDI in the Pacific region of the OECD, i.e. Australia, New Zealand, Japan, and Korea, are analysed for 1982–1997. The data set allowed two time periods i.e. the 1980s and the 1990s, and two different subgroups, i.e. Australia and New Zealand, and Japan and Korea to be distinguished. Statistical evidence indicates a heterogeneous response of US FDI towards different countries and for different time periods. Factors such as market size, income level and qualified and productive labour exert a significant impact on both the timing and the locational choice of US investors in the region.