The genus Hypericum—a valuable resource of anti-Staphylococcal leads

Simon Gibbons, Birgit Ohlendorf, Inga Johnsen

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64 Citations (Scopus)


In the present study, extracts of 34 species and varieties of the genus Hypericum were screened for activity against a clinical isolate of methicillin-resistant Staphylococcus aureus, which in addition possessed a multidrug efflux mechanism conferring a high level of resistance to therapeutically useful antibiotics. Thirty-three of the 34 chloroform extracts showed significant activity in a disk diffusion assay, and five extracts had minimum inhibitory concentrations of 64 μg/ml, indicating that this genus has great potential to yield compounds with potent activity against multidrug-resistant bacteria.
Original languageEnglish
Pages (from-to)300-304
Number of pages5
Issue number4
Publication statusPublished - 1 Jul 2002

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