The genus Hypericum—a valuable resource of anti-Staphylococcal leads

Simon Gibbons; Birgit Ohlendorf; Inga Johnsen

doi:10.1016/S0367-326X(02)00082-5

The genus Hypericum—a valuable resource of anti-Staphylococcal leads

Simon Gibbons, Birgit Ohlendorf, Inga Johnsen

Research output: Contribution to journal › Article › peer-review

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Abstract

In the present study, extracts of 34 species and varieties of the genus Hypericum were screened for activity against a clinical isolate of methicillin-resistant Staphylococcus aureus, which in addition possessed a multidrug efflux mechanism conferring a high level of resistance to therapeutically useful antibiotics. Thirty-three of the 34 chloroform extracts showed significant activity in a disk diffusion assay, and five extracts had minimum inhibitory concentrations of 64 μg/ml, indicating that this genus has great potential to yield compounds with potent activity against multidrug-resistant bacteria.

Original language	English
Pages (from-to)	300-304
Number of pages	5
Journal	Fitoterapia
Volume	73
Issue number	4
DOIs	https://doi.org/10.1016/S0367-326X(02)00082-5
Publication status	Published - 1 Jul 2002

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10.1016/S0367-326X(02)00082-5

https://linkinghub.elsevier.com/retrieve/pii/S0367326X02000825

Cite this

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abstract = "In the present study, extracts of 34 species and varieties of the genus Hypericum were screened for activity against a clinical isolate of methicillin-resistant Staphylococcus aureus, which in addition possessed a multidrug efflux mechanism conferring a high level of resistance to therapeutically useful antibiotics. Thirty-three of the 34 chloroform extracts showed significant activity in a disk diffusion assay, and five extracts had minimum inhibitory concentrations of 64 μg/ml, indicating that this genus has great potential to yield compounds with potent activity against multidrug-resistant bacteria.",

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AB - In the present study, extracts of 34 species and varieties of the genus Hypericum were screened for activity against a clinical isolate of methicillin-resistant Staphylococcus aureus, which in addition possessed a multidrug efflux mechanism conferring a high level of resistance to therapeutically useful antibiotics. Thirty-three of the 34 chloroform extracts showed significant activity in a disk diffusion assay, and five extracts had minimum inhibitory concentrations of 64 μg/ml, indicating that this genus has great potential to yield compounds with potent activity against multidrug-resistant bacteria.

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DO - 10.1016/S0367-326X(02)00082-5

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